LAG3 [The Human Chemical-Genetic Interaction Map Project]

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======= LAG3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LAG3
  * **<color #00a2e8>Official Name</color>**: lymphocyte activating 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3902|3902]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P18627|P18627]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LAG3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LAG3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/153337|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in lymphocyte activation. Binds to HLA class-II antigens.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|plasmacytoid dendritic cell activation|
|negative regulation of interleukin-2 biosynthetic process|
|negative regulation of regulatory T cell differentiation|
|MHC class II protein binding|
|regulation of interleukin-2 biosynthetic process|
|negative regulation of interleukin-2 production|
|positive regulation of natural killer cell mediated cytotoxicity|
|regulation of regulatory T cell differentiation|
|negative regulation of cytokine biosynthetic process|
|positive regulation of natural killer cell mediated immunity|
|negative regulation of T cell differentiation|
|regulation of natural killer cell mediated cytotoxicity|
|regulation of natural killer cell mediated immunity|
|negative regulation of lymphocyte differentiation|
|regulation of interleukin-2 production|
|positive regulation of leukocyte mediated cytotoxicity|
|positive regulation of cell killing|
|regulation of leukocyte mediated cytotoxicity|
|antigen processing and presentation of exogenous peptide antigen via MHC class II|
|antigen processing and presentation of peptide antigen via MHC class II|
|negative regulation of leukocyte differentiation|
|antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|
|regulation of cell killing|
|positive regulation of lymphocyte mediated immunity|
|regulation of cytokine biosynthetic process|
|negative regulation of T cell activation|
|negative regulation of leukocyte cell-cell adhesion|
|positive regulation of leukocyte mediated immunity|
|negative regulation of hemopoiesis|
|transmembrane signaling receptor activity|
|regulation of T cell differentiation|
|antigen binding|
|negative regulation of lymphocyte activation|
|regulation of lymphocyte mediated immunity|
|regulation of lymphocyte differentiation|
|negative regulation of leukocyte activation|
|negative regulation of cell-cell adhesion|
|antigen processing and presentation of exogenous peptide antigen|
|antigen processing and presentation of exogenous antigen|
|antigen processing and presentation of peptide antigen|
|negative regulation of cell activation|
|regulation of leukocyte mediated immunity|
|antigen processing and presentation|
|positive regulation of immune effector process|
|negative regulation of cell adhesion|
|regulation of leukocyte differentiation|
|negative regulation of cytokine production|
|regulation of leukocyte cell-cell adhesion|
|regulation of T cell activation|
|positive regulation of innate immune response|
|positive regulation of response to biotic stimulus|
|external side of plasma membrane|
|regulation of cell-cell adhesion|
|negative regulation of immune system process|
|regulation of hemopoiesis|
|regulation of innate immune response|
|regulation of immune effector process|
|positive regulation of defense response|
|positive regulation of multi-organism process|
|regulation of lymphocyte activation|
|regulation of response to biotic stimulus|
|positive regulation of response to external stimulus|
|regulation of leukocyte activation|
|adaptive immune response|
|regulation of cell activation|
|regulation of cell adhesion|
|regulation of cytokine production|
|negative regulation of cell differentiation|
|regulation of defense response|
|regulation of multi-organism process|
|positive regulation of immune response|
|leukocyte activation|
|negative regulation of developmental process|
|cell activation|
|regulation of response to external stimulus|
|negative regulation of protein metabolic process|
|regulation of immune response|
|positive regulation of immune system process|
|negative regulation of multicellular organismal process|
|negative regulation of macromolecule biosynthetic process|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|regulation of immune system process|
|regulation of cell differentiation|
|immune response|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp41|BI-2536 0.001μM R01 exp41]]|1.73|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2990
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -4.01 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LAG3 Expression in NALM6 Cells: -4.01'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>