LAMA5 [The Human Chemical-Genetic Interaction Map Project]

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======= LAMA5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LAMA5
  * **<color #00a2e8>Official Name</color>**: laminin subunit alpha 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3911|3911]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O15230|O15230]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LAMA5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LAMA5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601033|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes one of the vertebrate laminin alpha chains. Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. The protein encoded by this gene is the alpha-5 subunit of of laminin-10 (laminin-511), laminin-11 (laminin-521) and laminin-15 (laminin-523). [provided by RefSeq, Jun 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Laminin I|
|Laminin G 1|
|Laminin N|
|Laminin II|
|Laminin G 2|
|Laminin B|
|Laminin EGF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|laminin-10 complex|
|laminin-11 complex|
|laminin-5 complex|
|synaptic cleft|
|branching involved in salivary gland morphogenesis|
|cell-substrate adherens junction assembly|
|focal adhesion assembly|
|salivary gland morphogenesis|
|salivary gland development|
|adherens junction assembly|
|cell-substrate junction assembly|
|morphogenesis of a polarized epithelium|
|exocrine system development|
|branching involved in ureteric bud morphogenesis|
|substrate adhesion-dependent cell spreading|
|ureteric bud morphogenesis|
|mesonephric tubule morphogenesis|
|neural crest cell migration|
|nephron tubule morphogenesis|
|nephron epithelium morphogenesis|
|nephron morphogenesis|
|renal tubule morphogenesis|
|hair follicle development|
|skin epidermis development|
|molting cycle process|
|hair cycle process|
|neuromuscular junction|
|nephron tubule development|
|neural crest cell development|
|renal tubule development|
|odontogenesis of dentin-containing tooth|
|endothelial cell differentiation|
|mesenchymal cell development|
|stem cell development|
|adherens junction organization|
|kidney morphogenesis|
|ureteric bud development|
|mesonephric tubule development|
|mesonephric epithelium development|
|basement membrane|
|neural crest cell differentiation|
|mesonephros development|
|molting cycle|
|hair cycle|
|integrin-mediated signaling pathway|
|endothelium development|
|nephron epithelium development|
|gland morphogenesis|
|odontogenesis|
|nephron development|
|cell-matrix adhesion|
|regulation of embryonic development|
|kidney epithelium development|
|branching morphogenesis of an epithelial tube|
|integrin binding|
|extracellular matrix structural constituent|
|morphogenesis of embryonic epithelium|
|mesenchymal cell differentiation|
|stem cell differentiation|
|morphogenesis of a branching epithelium|
|cell junction assembly|
|morphogenesis of a branching structure|
|lung development|
|ameboidal-type cell migration|
|respiratory tube development|
|protein localization to plasma membrane|
|cell-substrate adhesion|
|respiratory system development|
|cell junction organization|
|mesenchyme development|
|protein localization to cell periphery|
|cell recognition|
|kidney development|
|renal system development|
|muscle organ development|
|epithelial tube morphogenesis|
|angiogenesis|
|urogenital system development|
|extracellular matrix organization|
|cilium assembly|
|collagen-containing extracellular matrix|
|cilium organization|
|skin development|
|extracellular structure organization|
|blood vessel morphogenesis|
|gland development|
|epidermis development|
|morphogenesis of an epithelium|
|plasma membrane bounded cell projection assembly|
|cell projection assembly|
|muscle structure development|
|protein localization to membrane|
|blood vessel development|
|cell-cell adhesion|
|vasculature development|
|cardiovascular system development|
|cell population proliferation|
|cell morphogenesis involved in differentiation|
|tissue morphogenesis|
|embryonic morphogenesis|
|tube morphogenesis|
|cytokine-mediated signaling pathway|
|epithelial cell differentiation|
|regulation of cell adhesion|
|cell morphogenesis|
|organelle assembly|
|cellular component morphogenesis|
|tube development|
|regulation of cell migration|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|regulation of cell motility|
|cell adhesion|
|biological adhesion|
|animal organ morphogenesis|
|cell migration|
|embryo development|
|regulation of locomotion|
|regulation of cellular component movement|
|cellular response to cytokine stimulus|
|cell motility|
|localization of cell|
|response to cytokine|
|cytoskeleton organization|
|epithelium development|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|locomotion|
|movement of cell or subcellular component|
|cellular protein localization|
|extracellular space|
|cellular macromolecule localization|
|regulation of cell population proliferation|
|cell development|
|tissue development|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11308
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.71 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LAMA5 Expression in NALM6 Cells: 1.71'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>