LAMTOR2 [The Human Chemical-Genetic Interaction Map Project]

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======= LAMTOR2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LAMTOR2
  * **<color #00a2e8>Official Name</color>**: late endosomal/lysosomal adaptor, MAPK and MTOR activator 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=28956|28956]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y2Q5|Q9Y2Q5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LAMTOR2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LAMTOR2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610389|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The product of this gene is highly conserved with a mouse protein associated with the cytoplasmic face of late endosomes and lysosomes. The mouse protein interacts with MAPK scaffold protein 1, a component of the mitogen-activated protein kinase pathway. In humans, a mutation in this gene has been associated with a primary immunodeficiency syndrome, and suggests a role for this protein in endosomal biogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2. {ECO:0000269|PubMed:20381137, ECO:0000269|PubMed:22980980}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Robl LC7|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Ragulator complex|
|positive regulation of TOR signaling|
|molecular adaptor activity|
|activation of MAPKK activity|
|cellular response to amino acid stimulus|
|tertiary granule membrane|
|specific granule membrane|
|guanyl-nucleotide exchange factor activity|
|regulation of TOR signaling|
|response to amino acid|
|late endosome|
|cell cycle arrest|
|regulation of macroautophagy|
|cellular response to acid chemical|
|endosome membrane|
|positive regulation of MAP kinase activity|
|lysosomal membrane|
|activation of protein kinase activity|
|regulation of autophagy|
|positive regulation of protein serine/threonine kinase activity|
|regulation of MAP kinase activity|
|response to acid chemical|
|MAPK cascade|
|signal transduction by protein phosphorylation|
|regulation of cell growth|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|regulation of protein serine/threonine kinase activity|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|positive regulation of protein kinase activity|
|positive regulation of MAPK cascade|
|negative regulation of cell cycle|
|positive regulation of kinase activity|
|myeloid leukocyte activation|
|cellular response to organonitrogen compound|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|positive regulation of transferase activity|
|cellular response to nitrogen compound|
|regulation of growth|
|regulated exocytosis|
|regulation of MAPK cascade|
|leukocyte mediated immunity|
|exocytosis|
|regulation of protein kinase activity|
|regulation of cellular catabolic process|
|regulation of kinase activity|
|leukocyte activation|
|protein phosphorylation|
|regulation of transferase activity|
|regulation of catabolic process|
|cell cycle process|
|response to organonitrogen compound|
|secretion by cell|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|export from cell|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|cell activation|
|response to nitrogen compound|
|immune effector process|
|secretion|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|regulation of cell cycle|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|phosphorylation|
|cell cycle|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|positive regulation of signal transduction|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|immune response|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp71|KU-0063794 3.8μM R02 exp71]]|-3.07|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|-2.19|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|-2.19|
|[[:results:exp70|INK128 0.2μM R02 exp70]]|-2.1|
|[[:results:exp308|Rapamycin 2μM plus FK-506 5μM R07 exp308]]|-1.98|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|-1.9|
|[[:results:exp519|RS-1 10μM R08 exp519]]|-1.89|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|-1.84|
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|-1.75|
|[[:results:exp307|Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307]]|-1.74|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|1.95|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|2.04|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|2.07|
|[[:results:exp211|AICAR 240μM R05 exp211]]|2.11|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|2.15|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|2.22|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|2.46|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|2.79|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|3.51|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|3.83|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:l:lamtor4|LAMTOR4]]|0.698|
|[[:human genes:f:flcn|FLCN]]|0.68|
|[[:human genes:f:fnip1|FNIP1]]|0.659|
|[[:human genes:w:wdr24|WDR24]]|0.652|
|[[:human genes:r:rraga|RRAGA]]|0.628|
|[[:human genes:m:mios|MIOS]]|0.607|
|[[:human genes:l:lamtor1|LAMTOR1]]|0.602|
|[[:human genes:l:lamtor3|LAMTOR3]]|0.562|
|[[:human genes:w:wdr59|WDR59]]|0.514|
|[[:human genes:t:tbc1d5|TBC1D5]]|0.495|
|[[:human genes:r:rptor|RPTOR]]|0.494|
|[[:human genes:l:lamtor5|LAMTOR5]]|0.481|
|[[:human genes:c:casp3|CASP3]]|0.47|
|[[:human genes:m:mlst8|MLST8]]|0.461|
|[[:human genes:v:vps41|VPS41]]|0.458|
|[[:human genes:k:klf13|KLF13]]|0.451|
|[[:human genes:f:fbxo11|FBXO11]]|0.451|
|[[:human genes:i:irf2|IRF2]]|0.442|
|[[:human genes:e:eif4g1|EIF4G1]]|0.415|
|[[:human genes:d:dohh|DOHH]]|0.414|
|[[:human genes:m:mtor|MTOR]]|0.412|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 54/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|1/28|
|bone|2/26|
|breast|3/33|
|central nervous system|2/56|
|cervix|2/4|
|colorectal|2/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|4/21|
|liver|2/20|
|lung|9/75|
|lymphocyte|2/16|
|ovary|3/26|
|pancreas|3/24|
|peripheral nervous system|1/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|2/9|
|thyroid|0/2|
|upper aerodigestive|3/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1839
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.42 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LAMTOR2 Expression in NALM6 Cells: 4.42'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>