LAMTOR3 [The Human Chemical-Genetic Interaction Map Project]

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======= LAMTOR3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LAMTOR3
  * **<color #00a2e8>Official Name</color>**: late endosomal/lysosomal adaptor, MAPK and MTOR activator 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8649|8649]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UHA4|Q9UHA4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LAMTOR3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LAMTOR3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603296|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2. {ECO:0000269|PubMed:20381137, ECO:0000269|PubMed:22980980}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|MAPKK1 Int|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Ragulator complex|
|kinase activator activity|
|positive regulation of TOR signaling|
|molecular adaptor activity|
|activation of MAPKK activity|
|cellular response to amino acid stimulus|
|tertiary granule membrane|
|specific granule membrane|
|regulation of TOR signaling|
|guanyl-nucleotide exchange factor activity|
|response to amino acid|
|cell cycle arrest|
|regulation of macroautophagy|
|cellular response to acid chemical|
|endosome membrane|
|positive regulation of MAP kinase activity|
|lysosomal membrane|
|activation of protein kinase activity|
|regulation of autophagy|
|positive regulation of protein serine/threonine kinase activity|
|regulation of MAP kinase activity|
|response to acid chemical|
|MAPK cascade|
|signal transduction by protein phosphorylation|
|focal adhesion|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|regulation of protein serine/threonine kinase activity|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|positive regulation of protein kinase activity|
|positive regulation of MAPK cascade|
|negative regulation of cell cycle|
|positive regulation of kinase activity|
|myeloid leukocyte activation|
|cellular response to organonitrogen compound|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|positive regulation of transferase activity|
|cellular response to nitrogen compound|
|regulated exocytosis|
|regulation of MAPK cascade|
|leukocyte mediated immunity|
|exocytosis|
|regulation of protein kinase activity|
|regulation of cellular catabolic process|
|regulation of kinase activity|
|leukocyte activation|
|protein phosphorylation|
|regulation of transferase activity|
|regulation of catabolic process|
|cell cycle process|
|response to organonitrogen compound|
|secretion by cell|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|export from cell|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|cell activation|
|response to nitrogen compound|
|immune effector process|
|secretion|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|regulation of cell cycle|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|phosphorylation|
|cell cycle|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|positive regulation of signal transduction|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|immune response|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp438|NN-Diethyl-meta-toluamide 500μM R08 exp438]]|-2.32|
|[[:results:exp333|All-trans-Retinoic-Acid 8μM R07 exp333]]|-1.94|
|[[:results:exp308|Rapamycin 2μM plus FK-506 5μM R07 exp308]]|-1.93|
|[[:results:exp415|Trichostatin-A 0.06μM R07 exp415]]|-1.9|
|[[:results:exp152|SGC2043 10μM R03 exp152]]|-1.81|
|[[:results:exp273|Cisplatin 0.35μM R06 exp273]]|-1.8|
|[[:results:exp477|DKK1 89ng/ml R08 exp477]]|-1.78|
|[[:results:exp279|D-Fructose 10000μM R06 exp279]]|-1.74|
|[[:results:exp372|Ibrutinib 1μM R07 exp372]]|-1.73|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|-1.72|
|[[:results:exp405|Tenofovir 10μM R07 exp405]]|-1.72|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|1.77|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|1.82|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|1.86|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|1.93|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|2.01|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|2.74|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|3.14|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:l:lamtor4|LAMTOR4]]|0.605|
|[[:human genes:l:lamtor2|LAMTOR2]]|0.562|
|[[:human genes:w:wdr24|WDR24]]|0.542|
|[[:human genes:l:lamtor5|LAMTOR5]]|0.523|
|[[:human genes:f:flcn|FLCN]]|0.516|
|[[:human genes:r:rraga|RRAGA]]|0.496|
|[[:human genes:v:vps41|VPS41]]|0.487|
|[[:human genes:f:fnip1|FNIP1]]|0.479|
|[[:human genes:w:wdr59|WDR59]]|0.449|
|[[:human genes:r:rptor|RPTOR]]|0.444|
|[[:human genes:d:dohh|DOHH]]|0.435|
|[[:human genes:t:tbc1d5|TBC1D5]]|0.434|
|[[:human genes:m:mlst8|MLST8]]|0.429|
|[[:human genes:b:bcs1l|BCS1L]]|0.407|
|[[:human genes:r:rbmx2|RBMX2]]|0.404|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 49/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/26|
|breast|4/33|
|central nervous system|4/56|
|cervix|1/4|
|colorectal|0/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|2/21|
|liver|1/20|
|lung|7/75|
|lymphocyte|4/16|
|ovary|1/26|
|pancreas|2/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|3/9|
|thyroid|0/2|
|upper aerodigestive|2/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10310
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.59 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LAMTOR3 Expression in NALM6 Cells: 4.59'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>