LAMTOR5 [The Human Chemical-Genetic Interaction Map Project]

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======= LAMTOR5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LAMTOR5
  * **<color #00a2e8>Official Name</color>**: late endosomal/lysosomal adaptor, MAPK and MTOR activator 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10542|10542]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O43504|O43504]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LAMTOR5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LAMTOR5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608521|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. When complexed to BIRC5, interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway. Down-regulates hepatitis B virus (HBV) replication. {ECO:0000269|PubMed:12773388, ECO:0000269|PubMed:22980980}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Ragulator complex|
|positive regulation of TORC1 signaling|
|viral genome replication|
|protein localization to lysosome|
|regulation of TORC1 signaling|
|positive regulation of TOR signaling|
|molecular adaptor activity|
|protein localization to vacuole|
|cellular response to amino acid stimulus|
|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|negative regulation of cysteine-type endopeptidase activity|
|regulation of TOR signaling|
|guanyl-nucleotide exchange factor activity|
|response to amino acid|
|cell cycle arrest|
|regulation of macroautophagy|
|regulation of cell size|
|viral life cycle|
|cellular response to acid chemical|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|regulation of cysteine-type endopeptidase activity|
|negative regulation of endopeptidase activity|
|lysosome|
|negative regulation of peptidase activity|
|response to virus|
|lysosomal membrane|
|regulation of autophagy|
|response to acid chemical|
|negative regulation of proteolysis|
|regulation of cellular component size|
|regulation of endopeptidase activity|
|regulation of peptidase activity|
|negative regulation of hydrolase activity|
|regulation of anatomical structure size|
|negative regulation of cell cycle|
|cellular response to organonitrogen compound|
|cellular response to nitrogen compound|
|viral process|
|regulation of proteolysis|
|protein localization to organelle|
|symbiotic process|
|negative regulation of catalytic activity|
|interspecies interaction between organisms|
|regulation of cellular catabolic process|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|regulation of catabolic process|
|negative regulation of cell death|
|cell cycle process|
|response to organonitrogen compound|
|positive regulation of intracellular signal transduction|
|negative regulation of cellular protein metabolic process|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|regulation of cell cycle|
|cellular response to endogenous stimulus|
|regulation of hydrolase activity|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|cell cycle|
|response to endogenous stimulus|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|cellular protein localization|
|cellular macromolecule localization|
|positive regulation of signal transduction|
|regulation of cell death|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp264|Arsenate 40μM R06 exp264]]|-1.86|
|[[:results:exp437|Ethanol 0.003 R08 exp437]]|-1.75|
|[[:results:exp82|Torin1 0.08μM R02 exp82]]|-1.72|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|1.81|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|1.96|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|2.09|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:w:wdr24|WDR24]]|0.597|
|[[:human genes:r:rptor|RPTOR]]|0.565|
|[[:human genes:l:lamtor4|LAMTOR4]]|0.563|
|[[:human genes:f:flcn|FLCN]]|0.558|
|[[:human genes:w:wdr59|WDR59]]|0.543|
|[[:human genes:d:dpagt1|DPAGT1]]|0.534|
|[[:human genes:t:thg1l|THG1L]]|0.524|
|[[:human genes:l:lamtor3|LAMTOR3]]|0.523|
|[[:human genes:e:eif4e|EIF4E]]|0.522|
|[[:human genes:d:dohh|DOHH]]|0.51|
|[[:human genes:g:gfpt1|GFPT1]]|0.505|
|[[:human genes:e:eny2|ENY2]]|0.498|
|[[:human genes:m:mios|MIOS]]|0.495|
|[[:human genes:g:gmppb|GMPPB]]|0.495|
|[[:human genes:f:fnip1|FNIP1]]|0.494|
|[[:human genes:c:ccdc101|CCDC101]]|0.492|
|[[:human genes:v:vps41|VPS41]]|0.484|
|[[:human genes:l:lamtor2|LAMTOR2]]|0.481|
|[[:human genes:r:rnmt|RNMT]]|0.478|
|[[:human genes:a:alg1|ALG1]]|0.472|
|[[:human genes:r:rtcb|RTCB]]|0.47|
|[[:human genes:s:seh1l|SEH1L]]|0.469|
|[[:human genes:n:nae1|NAE1]]|0.467|
|[[:human genes:t:thoc6|THOC6]]|0.466|
|[[:human genes:a:adsl|ADSL]]|0.466|
|[[:human genes:u:uap1|UAP1]]|0.464|
|[[:human genes:m:mtor|MTOR]]|0.46|
|[[:human genes:b:bak1|BAK1]]|0.457|
|[[:human genes:h:hspd1|HSPD1]]|0.453|
|[[:human genes:m:meaf6|MEAF6]]|0.452|
|[[:human genes:d:dhps|DHPS]]|0.452|
|[[:human genes:v:vhl|VHL]]|0.45|
|[[:human genes:t:triap1|TRIAP1]]|0.45|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.45|
|[[:human genes:m:med4|MED4]]|0.449|
|[[:human genes:c:cbfb|CBFB]]|0.449|
|[[:human genes:f:fbxo11|FBXO11]]|0.448|
|[[:human genes:g:gnb1l|GNB1L]]|0.447|
|[[:human genes:t:trnt1|TRNT1]]|0.447|
|[[:human genes:m:mapk14|MAPK14]]|0.447|
|[[:human genes:m:med16|MED16]]|0.445|
|[[:human genes:c:cycs|CYCS]]|0.444|
|[[:human genes:p:pax5|PAX5]]|0.442|
|[[:human genes:v:vrk1|VRK1]]|0.44|
|[[:human genes:s:serf2|SERF2]]|0.439|
|[[:human genes:h:haus8|HAUS8]]|0.438|
|[[:human genes:m:mllt1|MLLT1]]|0.438|
|[[:human genes:p:pmm2|PMM2]]|0.436|
|[[:human genes:t:tbc1d5|TBC1D5]]|0.434|
|[[:human genes:a:aars|AARS]]|0.432|
|[[:human genes:s:srp68|SRP68]]|0.432|
|[[:human genes:t:tbp|TBP]]|0.432|
|[[:human genes:f:faf2|FAF2]]|0.431|
|[[:human genes:r:rraga|RRAGA]]|0.431|
|[[:human genes:a:atp5j|ATP5J]]|0.43|
|[[:human genes:o:oraov1|ORAOV1]]|0.428|
|[[:human genes:t:tti2|TTI2]]|0.428|
|[[:human genes:d:dr1|DR1]]|0.427|
|[[:human genes:u:uhrf1|UHRF1]]|0.424|
|[[:human genes:m:march5|MARCH5]]|0.424|
|[[:human genes:y:yars|YARS]]|0.423|
|[[:human genes:a:atxn10|ATXN10]]|0.423|
|[[:human genes:l:lsmd1|LSMD1]]|0.42|
|[[:human genes:t:thoc3|THOC3]]|0.416|
|[[:human genes:r:rpe|RPE]]|0.412|
|[[:human genes:p:pelo|PELO]]|0.412|
|[[:human genes:t:tmem41b|TMEM41B]]|0.411|
|[[:human genes:u:uxt|UXT]]|0.411|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.41|
|[[:human genes:t:telo2|TELO2]]|0.41|
|[[:human genes:g:gtf2a2|GTF2A2]]|0.409|
|[[:human genes:a:alg2|ALG2]]|0.409|
|[[:human genes:r:rad1|RAD1]]|0.409|
|[[:human genes:a:atp5b|ATP5B]]|0.407|
|[[:human genes:t:timm13|TIMM13]]|0.405|
|[[:human genes:a:atp5o|ATP5O]]|0.405|
|[[:human genes:b:bap1|BAP1]]|0.405|
|[[:human genes:c:cbx3|CBX3]]|0.405|
|[[:human genes:c:casp9|CASP9]]|0.404|
|[[:human genes:g:ggnbp2|GGNBP2]]|0.403|
|[[:human genes:u:ubqln1|UBQLN1]]|0.403|
|[[:human genes:a:actr10|ACTR10]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6908
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.34 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LAMTOR5 Expression in NALM6 Cells: 5.34'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>