LARP4B [The Human Chemical-Genetic Interaction Map Project]

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======= LARP4B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LARP4B
  * **<color #00a2e8>Official Name</color>**: La ribonucleoprotein 4B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23185|23185]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q92615|Q92615]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LARP4B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LARP4B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616513|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Stimulates mRNA translation. {ECO:0000269|PubMed:20573744}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|La|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|polysomal ribosome|
|cytoplasmic stress granule|
|positive regulation of translation|
|positive regulation of cellular amide metabolic process|
|regulation of translation|
|regulation of cellular amide metabolic process|
|posttranscriptional regulation of gene expression|
|nucleolus|
|RNA binding|
|positive regulation of cellular protein metabolic process|
|positive regulation of protein metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|membrane|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|-2.31|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-2.28|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|-1.86|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|-1.84|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|1.72|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|1.72|
|[[:results:exp536|Vitamin-D3 40μM R08 exp536]]|1.72|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|1.74|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|1.82|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|1.87|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|1.88|
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|2.09|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|2.38|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hars|HARS]]|0.448|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4934
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.93 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LARP4B Expression in NALM6 Cells: 6.93'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>