LEUTX [The Human Chemical-Genetic Interaction Map Project]

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======= LEUTX =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LEUTX
  * **<color #00a2e8>Official Name</color>**: leucine twenty homeobox
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=342900|342900]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/A8MZ59|A8MZ59]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LEUTX&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LEUTX|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/618701|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Homeobox|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|sequence-specific DNA binding|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp464|Calcipotriol 5μM R08 exp464]]|-2.09|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|-2.02|
|[[:results:exp211|AICAR 240μM R05 exp211]]|-1.87|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|-1.75|
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|-1.72|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|1.77|
|[[:results:exp107|UMK57 0.6μM R03 exp107]]|1.85|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|1.88|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|1.92|
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|1.97|
|[[:results:exp363|GSK-J4 1-1.25μM to day4 R07 exp363]]|1.99|
|[[:results:exp483|FTY720 3μM R08 exp483]]|2.15|
|[[:results:exp77|Prochlorperazine 5.2μM R02 exp77]]|2.54|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7001
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LEUTX Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>