LGR4 [The Human Chemical-Genetic Interaction Map Project]

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======= LGR4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LGR4
  * **<color #00a2e8>Official Name</color>**: leucine rich repeat containing G protein-coupled receptor 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55366|55366]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BXB1|Q9BXB1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LGR4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LGR4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606666|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a G-protein coupled receptor that binds R-spondins and activates the Wnt signaling pathway. This Wnt signaling pathway activation is necessary for proper development of many organs of the body. [provided by RefSeq, Oct 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and is involved in the formation of various organs. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Its function as activator of the Wnt signaling pathway is required for the development of various organs, including liver, kidney, intestine, bone, reproductive tract and eye. May also act as a receptor for norrin (NDP), such results however require additional confirmation in vivo. Required during spermatogenesis to activate the Wnt signaling pathway in peritubular myoid cells. Required for the maintenance of intestinal stem cells and Paneth cell differentiation in postnatal intestinal crypts. Acts as a regulator of bone formation and remodeling. Involved in kidney development; required for maintaining the ureteric bud in an undifferentiated state. Involved in the development of the anterior segment of the eye. Required during erythropoiesis. Also acts as a negative regulator of innate immunity by inhibiting TLR2/TLR4 associated pattern-recognition and proinflammatory cytokine production. Plays an important role in regulating the circadian rhythms of plasma lipids, partially through regulating the rhythmic expression of MTTP (By similarity). {ECO:0000250|UniProtKB:A2ARI4, ECO:0000269|PubMed:21693646, ECO:0000269|PubMed:21727895, ECO:0000269|PubMed:21909076, ECO:0000269|PubMed:22815884, ECO:0000269|PubMed:23444378, ECO:0000269|PubMed:23756652}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|LRR 4|
|LRRNT|
|7tm 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|intestinal stem cell homeostasis|
|cell-cell signaling involved in kidney development|
|cell-cell signaling involved in metanephros development|
|canonical Wnt signaling pathway involved in metanephric kidney development|
|Wnt signaling pathway involved in kidney development|
|epithelial cell proliferation involved in renal tubule morphogenesis|
|protein-hormone receptor activity|
|metanephric nephron tubule morphogenesis|
|metanephric glomerulus development|
|metanephric tubule morphogenesis|
|metanephric nephron tubule development|
|cell differentiation involved in metanephros development|
|metanephric nephron epithelium development|
|positive regulation of branching involved in ureteric bud morphogenesis|
|metanephric tubule development|
|metanephric nephron morphogenesis|
|metanephric epithelium development|
|positive regulation of mesonephros development|
|regulation of branching involved in ureteric bud morphogenesis|
|male genitalia development|
|regulation of mesonephros development|
|metanephros morphogenesis|
|metanephric nephron development|
|positive regulation of morphogenesis of an epithelium|
|negative regulation of toll-like receptor signaling pathway|
|activation of adenylate cyclase activity|
|G protein-coupled peptide receptor activity|
|positive regulation of kidney development|
|cell differentiation involved in kidney development|
|bone remodeling|
|genitalia development|
|negative regulation of cold-induced thermogenesis|
|bone mineralization|
|glomerulus development|
|regulation of kidney development|
|regulation of morphogenesis of a branching structure|
|circadian regulation of gene expression|
|nephron tubule morphogenesis|
|nephron epithelium morphogenesis|
|nephron morphogenesis|
|negative regulation of cytokine secretion|
|renal tubule morphogenesis|
|regulation of toll-like receptor signaling pathway|
|hair follicle development|
|skin epidermis development|
|molting cycle process|
|hair cycle process|
|nephron tubule development|
|renal tubule development|
|positive regulation of animal organ morphogenesis|
|metanephros development|
|kidney morphogenesis|
|epithelial cell proliferation|
|canonical Wnt signaling pathway|
|molting cycle|
|hair cycle|
|biomineral tissue development|
|biomineralization|
|nephron epithelium development|
|tissue remodeling|
|nephron development|
|osteoblast differentiation|
|adenylate cyclase-activating G protein-coupled receptor signaling pathway|
|kidney epithelium development|
|digestive tract development|
|negative regulation of protein secretion|
|transmembrane signaling receptor activity|
|negative regulation of peptide secretion|
|circadian rhythm|
|digestive system development|
|regulation of cold-induced thermogenesis|
|positive regulation of canonical Wnt signaling pathway|
|cAMP-mediated signaling|
|male sex differentiation|
|hormone-mediated signaling pathway|
|cyclic-nucleotide-mediated signaling|
|positive regulation of Wnt signaling pathway|
|regulation of morphogenesis of an epithelium|
|negative regulation of protein transport|
|negative regulation of establishment of protein localization|
|homeostasis of number of cells|
|negative regulation of secretion by cell|
|regulation of cytokine secretion|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|negative regulation of secretion|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|regulation of animal organ morphogenesis|
|ossification|
|sex differentiation|
|kidney development|
|negative regulation of cytokine production|
|rhythmic process|
|regulation of canonical Wnt signaling pathway|
|renal system development|
|epithelial tube morphogenesis|
|urogenital system development|
|second-messenger-mediated signaling|
|cell-cell signaling by wnt|
|Wnt signaling pathway|
|regulation of Wnt signaling pathway|
|skin development|
|epidermis development|
|reproductive structure development|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|reproductive system development|
|morphogenesis of an epithelium|
|negative regulation of immune system process|
|regulation of innate immune response|
|regulation of protein secretion|
|negative regulation of transport|
|regulation of peptide secretion|
|regulation of response to biotic stimulus|
|spermatogenesis|
|cell population proliferation|
|male gamete generation|
|tissue morphogenesis|
|cellular response to hormone stimulus|
|tube morphogenesis|
|developmental process involved in reproduction|
|gamete generation|
|regulation of cytokine production|
|regulation of protein transport|
|G protein-coupled receptor activity|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of defense response|
|innate immune response|
|regulation of multi-organism process|
|regulation of secretion|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|tube development|
|response to hormone|
|defense response to other organism|
|animal organ morphogenesis|
|multi-organism reproductive process|
|regulation of protein localization|
|regulation of anatomical structure morphogenesis|
|regulation of response to external stimulus|
|epithelium development|
|cell-cell signaling|
|regulation of immune response|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|cellular response to endogenous stimulus|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|response to other organism|
|response to external biotic stimulus|
|G protein-coupled receptor signaling pathway|
|response to biotic stimulus|
|negative regulation of RNA metabolic process|
|defense response|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|integral component of plasma membrane|
|reproductive process|
|reproduction|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|negative regulation of response to stimulus|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|positive regulation of signal transduction|
|regulation of immune system process|
|intracellular signal transduction|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of transport|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10082
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.18 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LGR4 Expression in NALM6 Cells: -0.18'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>