LIFR [The Human Chemical-Genetic Interaction Map Project]

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======= LIFR =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LIFR
  * **<color #00a2e8>Official Name</color>**: LIF receptor subunit alpha
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3977|3977]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P42702|P42702]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LIFR&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LIFR|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/151443|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein that belongs to the type I cytokine receptor family. This protein combines with a high-affinity converter subunit, gp130, to form a receptor complex that mediates the action of the leukemia inhibitory factor, a polyfunctional cytokine that is involved in cellular differentiation, proliferation and survival in the adult and the embryo. Mutations in this gene cause Schwartz-Jampel syndrome type 2, a disease belonging to the group of the bent-bone dysplasias. A translocation that involves the promoter of this gene, t(5;8)(p13;q12) with the pleiomorphic adenoma gene 1, is associated with salivary gland pleiomorphic adenoma, a common type of benign epithelial tumor of the salivary gland. Multiple splice variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the biological activity of LIF by blocking its binding to receptors on target cells.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|fn3|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|leukemia inhibitory factor receptor activity|
|oncostatin-M receptor activity|
|oncostatin-M-mediated signaling pathway|
|leukemia inhibitory factor signaling pathway|
|ciliary neurotrophic factor receptor binding|
|ciliary neurotrophic factor receptor activity|
|ciliary neurotrophic factor-mediated signaling pathway|
|growth factor binding|
|cytokine binding|
|cytokine receptor activity|
|regulation of cytokine-mediated signaling pathway|
|regulation of response to cytokine stimulus|
|receptor complex|
|external side of plasma membrane|
|cytokine-mediated signaling pathway|
|enzyme linked receptor protein signaling pathway|
|positive regulation of cell population proliferation|
|cellular response to cytokine stimulus|
|response to cytokine|
|integral component of plasma membrane|
|regulation of cell population proliferation|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|-2.15|
|[[:results:exp484|GSK-J5 1.5μM R08 exp484]]|-2.09|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|-1.78|
|[[:results:exp530|Thioridazine 5μM R08 exp530]]|-1.77|
|[[:results:exp292|Menadione 5μM R06 exp292]]|1.82|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|1.9|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17908
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.54 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LIFR Expression in NALM6 Cells: -0.54'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>