LIN28A [The Human Chemical-Genetic Interaction Map Project]

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======= LIN28A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LIN28A
  * **<color #00a2e8>Official Name</color>**: lin-28 homolog A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=79727|79727]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H9Z2|Q9H9Z2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LIN28A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LIN28A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611043|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  RNA-binding protein that inhibits processing of pre-let- 7 miRNAs and regulates translation of mRNAs that control developmental timing, pluripotency and metabolism (PubMed:21247876). Seems to recognize a common structural G- quartet (G4) feature in its miRNA and mRNA targets (Probable). 'Translational enhancer' that drives specific mRNAs to polysomes and increases the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in mRNA stabilization. Binds IGF2 mRNA, MYOD1 mRNA, ARBP/36B4 ribosomal protein mRNA and its own mRNA. Essential for skeletal muscle differentiation program through the translational up-regulation of IGF2 expression. Suppressor of microRNA (miRNA) biogenesis, including that of let-7, miR107, miR-143 and miR-200c. Specifically binds the miRNA precursors (pre-miRNAs), recognizing an 5'-GGAG-3' motif found in pre-miRNA terminal loop, and recruits ZCCHC11/TUT4 uridylyltransferase. This results in the terminal uridylation of target pre-miRNAs. Uridylated pre-miRNAs fail to be processed by Dicer and undergo degradation. The repression of let- 7 expression is required for normal development and contributes to maintain the pluripotent state by preventing let-7-mediated differentiation of embryonic stem cells (PubMed:18951094, PubMed:19703396, PubMed:22118463, PubMed:22898984). Localized to the periendoplasmic reticulum area, binds to a large number of spliced mRNAs and inhibits the translation of mRNAs destined for the ER, reducing the synthesis of transmembrane proteins, ER or Golgi lumen proteins, and secretory proteins. Binds to and enhances the translation of mRNAs for several metabolic enzymes, such as PFKP, PDHA1 or SDHA, increasing glycolysis and oxidative phosphorylation. Which, with the let-7 repression may enhance tissue repair in adult tissue (By similarity). {ECO:0000250|UniProtKB:Q8K3Y3, ECO:0000269|PubMed:18951094, ECO:0000269|PubMed:19703396, ECO:0000269|PubMed:21247876, ECO:0000269|PubMed:22118463, ECO:0000269|PubMed:22898984, ECO:0000305}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CSD|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|polysome binding|
|G-quadruplex RNA binding|
|miRNA catabolic process|
|positive regulation of cell proliferation involved in kidney development|
|positive regulation of production of miRNAs involved in gene silencing by miRNA|
|positive regulation of cytoplasmic translation|
|sequence-specific mRNA binding|
|regulation of cell proliferation involved in kidney development|
|pre-miRNA processing|
|regulation of production of miRNAs involved in gene silencing by miRNA|
|regulation of production of small RNA involved in gene silencing by RNA|
|miRNA metabolic process|
|translation initiation factor binding|
|positive regulation of gene silencing by miRNA|
|positive regulation of posttranscriptional gene silencing|
|negative regulation of glial cell differentiation|
|ncRNA catabolic process|
|production of miRNAs involved in gene silencing by miRNA|
|miRNA binding|
|regulation of cytoplasmic translation|
|production of small RNA involved in gene silencing by RNA|
|dsRNA processing|
|positive regulation of TOR signaling|
|positive regulation of kidney development|
|negative regulation of gliogenesis|
|polysome|
|gene silencing by miRNA|
|regulation of kidney development|
|posttranscriptional gene silencing by RNA|
|posttranscriptional gene silencing|
|rough endoplasmic reticulum|
|somatic stem cell population maintenance|
|cytoplasmic stress granule|
|cellular response to glucose stimulus|
|regulation of glial cell differentiation|
|cellular response to hexose stimulus|
|cellular response to monosaccharide stimulus|
|cellular response to carbohydrate stimulus|
|P-body|
|gene silencing by RNA|
|regulation of gene silencing by miRNA|
|cellular glucose homeostasis|
|regulation of gene silencing by RNA|
|regulation of posttranscriptional gene silencing|
|regulation of TOR signaling|
|regulation of gliogenesis|
|positive regulation of translation|
|regulation of gene silencing|
|negative regulation of translation|
|RNA 3-end processing|
|stem cell population maintenance|
|maintenance of cell number|
|response to glucose|
|response to hexose|
|negative regulation of cellular amide metabolic process|
|response to monosaccharide|
|positive regulation of cellular amide metabolic process|
|gene silencing|
|ribonucleoprotein complex|
|stem cell differentiation|
|positive regulation of protein kinase B signaling|
|response to carbohydrate|
|glucose homeostasis|
|carbohydrate homeostasis|
|regulation of protein kinase B signaling|
|regulation of gene expression, epigenetic|
|RNA catabolic process|
|germ cell development|
|negative regulation of neurogenesis|
|negative regulation of nervous system development|
|negative regulation of cell development|
|regulation of translation|
|cellular process involved in reproduction in multicellular organism|
|positive regulation of neuron differentiation|
|nucleobase-containing compound catabolic process|
|ncRNA processing|
|regulation of cellular amide metabolic process|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|positive regulation of neurogenesis|
|ncRNA metabolic process|
|organic cyclic compound catabolic process|
|posttranscriptional regulation of gene expression|
|positive regulation of nervous system development|
|positive regulation of cell development|
|regulation of neuron differentiation|
|developmental process involved in reproduction|
|gamete generation|
|negative regulation of cell differentiation|
|cellular chemical homeostasis|
|regulation of neurogenesis|
|multicellular organismal reproductive process|
|sexual reproduction|
|zinc ion binding|
|multicellular organism reproduction|
|nucleolus|
|RNA processing|
|cellular homeostasis|
|cellular macromolecule catabolic process|
|positive regulation of cell population proliferation|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|positive regulation of cell differentiation|
|multi-organism reproductive process|
|positive regulation of intracellular signal transduction|
|negative regulation of cellular protein metabolic process|
|macromolecule catabolic process|
|cellular response to oxygen-containing compound|
|negative regulation of protein metabolic process|
|chemical homeostasis|
|negative regulation of multicellular organismal process|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|RNA binding|
|reproductive process|
|reproduction|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|neurogenesis|
|homeostatic process|
|cell development|
|positive regulation of signal transduction|
|RNA metabolic process|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|organic substance catabolic process|
|cellular catabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp59|UMK57 1μM R01 exp59]]|1.71|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|2.09|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11589
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.34 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LIN28A Expression in NALM6 Cells: 2.34'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>