LIPT1 [The Human Chemical-Genetic Interaction Map Project]

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======= LIPT1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LIPT1
  * **<color #00a2e8>Official Name</color>**: lipoyltransferase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51601|51601]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y234|Q9Y234]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LIPT1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LIPT1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610284|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The process of transferring lipoic acid to proteins is a two-step process. The first step is the activation of lipoic acid by lipoate-activating enzyme to form lipoyl-AMP. For the second step, the protein encoded by this gene transfers the lipoyl moiety to apoproteins. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 13. Read-through transcription also exists between this gene and the neighboring downstream mitochondrial ribosomal protein L30 (MRPL30) gene. [provided by RefSeq, Mar 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the transfer of the lipoyl group from lipoyl- AMP to the specific lysine residue of lipoyl domains of lipoate- dependent enzymes. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|BPL LplA LipB|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein lipoylation|
|protein-cofactor linkage|
|transferase activity, transferring acyl groups|
|protein maturation|
|peptidyl-lysine modification|
|mitochondrial matrix|
|peptidyl-amino acid modification|
|lipid metabolic process|
|mitochondrion|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|-2.45|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|-2.14|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|-2.13|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|-1.83|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|-1.78|
|[[:results:exp140|Nicotinate 1000μM R03 exp140]]|-1.78|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|-1.7|
|[[:results:exp348|Cyclosporin-A 3μM R07 exp348]]|1.94|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|2.14|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|2.2|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.37|
|[[:results:exp519|RS-1 10μM R08 exp519]]|2.44|
|[[:results:exp211|AICAR 240μM R05 exp211]]|2.58|
|[[:results:exp116|AICAR 240μM R03 exp116]]|2.86|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:l:lipt2|LIPT2]]|0.631|
|[[:human genes:l:lias|LIAS]]|0.62|
|[[:human genes:d:dld|DLD]]|0.579|
|[[:human genes:f:fdx1|FDX1]]|0.551|
|[[:human genes:s:slc25a19|SLC25A19]]|0.513|
|[[:human genes:g:gcsh|GCSH]]|0.498|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 3/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 692
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.48 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LIPT1 Expression in NALM6 Cells: 3.48'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>