LIPT2 [The Human Chemical-Genetic Interaction Map Project]

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======= LIPT2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LIPT2
  * **<color #00a2e8>Official Name</color>**: lipoyl(octanoyl) transferase 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=387787|387787]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/A6NK58|A6NK58]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LIPT2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LIPT2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617659|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a mitochondrial protein that catalyzes the transfer of octanoic acid to lipoate-dependent enzymes such as octanoyl-ACP. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes, which catalyze essential redox reactions (PubMed:28757203). Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity). {ECO:0000250, ECO:0000269|PubMed:28757203}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|BPL LplA LipB|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|lipoyl(octanoyl) transferase activity|
|octanoyl transferase activity (acting on glycine-cleavage complex H protein)|
|positive regulation of oxygen metabolic process|
|regulation of oxygen metabolic process|
|protein lipoylation|
|protein-cofactor linkage|
|ligase activity|
|protein maturation|
|peptidyl-lysine modification|
|mitochondrial matrix|
|peptidyl-amino acid modification|
|mitochondrion|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|-2.36|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|-2.27|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|-2.14|
|[[:results:exp129|Isonicotinamide 500μM R03 exp129]]|-1.86|
|[[:results:exp493|IL-3 9ng/ml R08 exp493]]|-1.8|
|[[:results:exp432|YM155 0.001μM R08 exp432]]|-1.78|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|1.82|
|[[:results:exp519|RS-1 10μM R08 exp519]]|1.84|
|[[:results:exp183|IU1-C 25μM R04 exp183]]|1.85|
|[[:results:exp359|FK-506 30μM R07 exp359]]|1.99|
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|2.08|
|[[:results:exp116|AICAR 240μM R03 exp116]]|2.37|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|2.39|
|[[:results:exp465|Cannabidiol 13μM R08 exp465]]|2.61|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|2.67|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:l:lipt1|LIPT1]]|0.631|
|[[:human genes:l:lias|LIAS]]|0.524|
|[[:human genes:g:gcsh|GCSH]]|0.508|
|[[:human genes:t:tpk1|TPK1]]|0.503|
|[[:human genes:s:slc25a19|SLC25A19]]|0.488|
|[[:human genes:i:iba57|IBA57]]|0.454|
|[[:human genes:f:fdx1|FDX1]]|0.433|
|[[:human genes:d:dld|DLD]]|0.431|
|[[:human genes:g:glrx5|GLRX5]]|0.431|
|[[:human genes:a:abhd11|ABHD11]]|0.42|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.412|
|[[:human genes:n:nfu1|NFU1]]|0.41|
|[[:human genes:s:suclg1|SUCLG1]]|0.403|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 812
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.89 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LIPT2 Expression in NALM6 Cells: 0.89'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>