LONP2 [The Human Chemical-Genetic Interaction Map Project]

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======= LONP2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LONP2
  * **<color #00a2e8>Official Name</color>**: lon peptidase 2, peroxisomal
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=83752|83752]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q86WA8|Q86WA8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LONP2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LONP2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617774|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  In human, peroxisomes function primarily to catalyze fatty acid beta-oxidation and, as a by-product, produce hydrogen peroxide and superoxide. The protein encoded by this gene is an ATP-dependent protease that likely plays a role in maintaining overall peroxisome homeostasis as well as proteolytically degrading peroxisomal proteins damaged by oxidation. The protein has an N-terminal Lon N substrate recognition domain, an ATPase domain, a proteolytic domain, and, in some isoforms, a C-terminal peroxisome targeting sequence. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**:  ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import (By similarity). May indirectly regulate peroxisomal fatty acid beta-oxidation through degradation of the self-processed forms of TYSND1. {ECO:0000255|HAMAP- Rule:MF_03121, ECO:0000269|PubMed:22002062}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Lon C|
|LON|
|AAA|
|AAA 5|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ATP-dependent peptidase activity|
|protein import into peroxisome matrix|
|peroxisomal membrane transport|
|regulation of fatty acid beta-oxidation|
|protein quality control for misfolded or incompletely synthesized proteins|
|regulation of fatty acid oxidation|
|protein transmembrane import into intracellular organelle|
|intracellular protein transmembrane transport|
|peroxisomal matrix|
|regulation of lipid catabolic process|
|protein transmembrane transport|
|establishment of protein localization to peroxisome|
|protein targeting to peroxisome|
|protein localization to peroxisome|
|peroxisomal transport|
|peroxisome organization|
|peptidase activity|
|regulation of fatty acid metabolic process|
|protease binding|
|peroxisome|
|protein import|
|protein processing|
|serine-type endopeptidase activity|
|regulation of cellular ketone metabolic process|
|protein maturation|
|enzyme binding|
|protein targeting|
|regulation of lipid metabolic process|
|regulation of small molecule metabolic process|
|establishment of protein localization to organelle|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|protein catabolic process|
|protein localization to organelle|
|regulation of cellular catabolic process|
|cellular macromolecule catabolic process|
|response to organic cyclic compound|
|intracellular protein transport|
|regulation of catabolic process|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|proteolysis|
|transmembrane transport|
|ATP binding|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|organic substance catabolic process|
|cellular catabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|1.83|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|2.43|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11584
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.84 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LONP2 Expression in NALM6 Cells: 6.84'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>