LOXL3 [The Human Chemical-Genetic Interaction Map Project]

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======= LOXL3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LOXL3
  * **<color #00a2e8>Official Name</color>**: lysyl oxidase like 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=84695|84695]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P58215|P58215]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LOXL3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LOXL3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607163|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a lysyl oxidase, which likely functions as an amine oxidase and plays a role in the formation of crosslinks in collagens and elastin. Deletion of the related gene in mouse causes neonatal mortality with cleft palate, spine deformity, and defects in collagen organization. A mutation in this gene was found in a family with Stickler syndrome. [provided by RefSeq, Sep 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Protein-lysine 6-oxidase that mediates the oxidation of peptidyl lysine residues to allysine in target proteins (PubMed:17018530, PubMed:28065600). Catalyzes the post- translational oxidative deamination of peptidyl lysine residues in precursors of elastin and different types of collagens, a prerequisite in the formation of cross-links between collagens and elastin (PubMed:17018530). Required for somite boundary formation by catalyzing oxidation of fibronectin (FN1), enhancing integrin signaling in myofibers and their adhesion to the myotendinous junction (MTJ) (By similarity). Acts as a regulator of inflammatory response by inhibiting differentiation of naive CD4(+) T-cells into T-helper Th17 or regulatory T-cells (Treg): acts by interacting with STAT3 in the nucleus and catalyzing both deacetylation and oxidation of lysine residues on STAT3, leading to disrupt STAT3 dimerization and inhibit STAT3 transcription activity (PubMed:28065600). Oxidation of lysine residues to allysine on STAT3 preferentially takes place on lysine residues that are acetylated (PubMed:28065600). Also able to catalyze deacetylation of lysine residues on STAT3 (PubMed:28065600). {ECO:0000250|UniProtKB:Q9Z175, ECO:0000269|PubMed:17018530, ECO:0000269|PubMed:28065600}. Isoform 2: Shows protein-lysine 6-oxidase activity toward elastin and different types of collagens, with the highest activity toward collagen type IV (PubMed:17018530). {ECO:0000269|PubMed:17018530}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Lysyl oxidase|
|SRCR|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|fibronectin fibril organization|
|negative regulation of T-helper 17 cell lineage commitment|
|protein-lysine 6-oxidase activity|
|peptidyl-lysine oxidation|
|regulation of T-helper 17 cell lineage commitment|
|positive regulation of integrin-mediated signaling pathway|
|negative regulation of T-helper 17 cell differentiation|
|negative regulation of T-helper 17 type immune response|
|negative regulation of cell fate commitment|
|protein oxidation|
|regulation of integrin-mediated signaling pathway|
|negative regulation of T-helper cell differentiation|
|regulation of T-helper 17 cell differentiation|
|regulation of T-helper 17 type immune response|
|negative regulation of CD4-positive, alpha-beta T cell differentiation|
|negative regulation of alpha-beta T cell differentiation|
|fibronectin binding|
|regulation of cell fate commitment|
|negative regulation of CD4-positive, alpha-beta T cell activation|
|regulation of T-helper cell differentiation|
|negative regulation of alpha-beta T cell activation|
|negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|negative regulation of T cell differentiation|
|negative regulation of adaptive immune response|
|regulation of CD4-positive, alpha-beta T cell differentiation|
|collagen fibril organization|
|scavenger receptor activity|
|negative regulation of lymphocyte differentiation|
|copper ion binding|
|regulation of CD4-positive, alpha-beta T cell activation|
|regulation of alpha-beta T cell differentiation|
|epithelial to mesenchymal transition|
|somite development|
|roof of mouth development|
|regulation of alpha-beta T cell activation|
|negative regulation of leukocyte differentiation|
|spinal cord development|
|negative regulation of T cell activation|
|negative regulation of immune effector process|
|negative regulation of leukocyte cell-cell adhesion|
|negative regulation of hemopoiesis|
|regulation of T cell differentiation|
|regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|negative regulation of lymphocyte activation|
|negative regulation of immune response|
|mesenchymal cell differentiation|
|regulation of adaptive immune response|
|regulation of lymphocyte differentiation|
|lung development|
|respiratory tube development|
|negative regulation of cell-cell adhesion|
|negative regulation of leukocyte activation|
|respiratory system development|
|negative regulation of cell activation|
|mesenchyme development|
|regulation of leukocyte differentiation|
|negative regulation of cell adhesion|
|regulation of leukocyte cell-cell adhesion|
|peptidyl-lysine modification|
|regulation of T cell activation|
|extracellular matrix organization|
|extracellular structure organization|
|regulation of cell-cell adhesion|
|negative regulation of immune system process|
|regulation of hemopoiesis|
|supramolecular fiber organization|
|regulation of immune effector process|
|inflammatory response|
|regulation of lymphocyte activation|
|endocytosis|
|regulation of leukocyte activation|
|regulation of cell activation|
|import into cell|
|regulation of cell adhesion|
|negative regulation of cell differentiation|
|tube development|
|peptidyl-amino acid modification|
|negative regulation of developmental process|
|oxidation-reduction process|
|embryo development|
|central nervous system development|
|epithelium development|
|regulation of immune response|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|defense response|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|extracellular space|
|negative regulation of response to stimulus|
|positive regulation of signal transduction|
|regulation of immune system process|
|negative regulation of gene expression|
|tissue development|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|protein-containing complex subunit organization|
|extracellular region|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|1.78|
|[[:results:exp10|CCCP 0.1μM R00 exp10]]|1.81|
|[[:results:exp31|Rifampicin 1μM R00 exp31]]|1.88|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3923
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.02 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LOXL3 Expression in NALM6 Cells: 3.02'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>