LPCAT1 [The Human Chemical-Genetic Interaction Map Project]

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======= LPCAT1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LPCAT1
  * **<color #00a2e8>Official Name</color>**: lysophosphatidylcholine acyltransferase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=79888|79888]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8NF37|Q8NF37]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LPCAT1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LPCAT1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610472|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the 1-acyl-sn-glycerol-3-phosphate acyltransferase family of proteins. The encoded enzyme plays a role in phospholipid metabolism, specifically in the conversion of lysophosphatidylcholine to phosphatidylcholine in the presence of acyl-CoA. This process is important in the synthesis of lung surfactant and platelet-activating factor (PAF). Elevated expression of this gene may contribute to the progression of oral squamous cell, prostate, breast, and other human cancers. [provided by RefSeq, Sep 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Possesses both acyltransferase and acetyltransferase activities (PubMed:16864775, PubMed:21498505). Activity is calcium-independent (By similarity). Mediates the conversion of 1- acyl-sn-glycero-3-phosphocholine (LPC) into phosphatidylcholine (PC) (PubMed:21498505). Displays a clear preference for saturated fatty acyl-CoAs, and 1-myristoyl or 1-palmitoyl LPC as acyl donors and acceptors, respectively (PubMed:16704971). May synthesize phosphatidylcholine in pulmonary surfactant, thereby playing a pivotal role in respiratory physiology (PubMed:16864775). Involved in the regulation of lipid droplet number and size (PubMed:25491198). {ECO:0000250|UniProtKB:Q3TFD2, ECO:0000269|PubMed:16864775, ECO:0000269|PubMed:21498505, ECO:0000269|PubMed:25491198}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Acyltransferase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|1-alkenylglycerophosphocholine O-acyltransferase activity|
|1-alkylglycerophosphocholine O-acyltransferase activity|
|negative regulation of phosphatidylcholine biosynthetic process|
|1-alkylglycerophosphocholine O-acetyltransferase activity|
|negative regulation of phospholipid biosynthetic process|
|1-acylglycerophosphocholine O-acyltransferase activity|
|regulation of phosphatidylcholine biosynthetic process|
|negative regulation of phospholipid metabolic process|
|surfactant homeostasis|
|chemical homeostasis within a tissue|
|regulation of phospholipid biosynthetic process|
|phosphatidylglycerol acyl-chain remodeling|
|phosphatidylcholine acyl-chain remodeling|
|phosphatidylglycerol metabolic process|
|phosphatidylcholine biosynthetic process|
|phosphatidic acid biosynthetic process|
|phosphatidic acid metabolic process|
|negative regulation of lipid biosynthetic process|
|azurophil granule membrane|
|phosphatidylcholine metabolic process|
|lipid droplet|
|negative regulation of lipid metabolic process|
|regulation of phospholipid metabolic process|
|retina development in camera-type eye|
|regulation of lipid biosynthetic process|
|tissue homeostasis|
|ammonium ion metabolic process|
|glycerophospholipid biosynthetic process|
|positive regulation of protein catabolic process|
|glycerolipid biosynthetic process|
|phospholipid biosynthetic process|
|glycerophospholipid metabolic process|
|camera-type eye development|
|multicellular organismal homeostasis|
|anatomical structure homeostasis|
|eye development|
|visual system development|
|sensory system development|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|regulation of protein catabolic process|
|regulation of lipid metabolic process|
|positive regulation of catabolic process|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|organophosphate biosynthetic process|
|sensory organ development|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|lipid biosynthetic process|
|myeloid leukocyte activation|
|Golgi membrane|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulated exocytosis|
|calcium ion binding|
|leukocyte mediated immunity|
|exocytosis|
|organophosphate metabolic process|
|leukocyte activation|
|endoplasmic reticulum membrane|
|cellular lipid metabolic process|
|Golgi apparatus|
|regulation of catabolic process|
|secretion by cell|
|endoplasmic reticulum|
|export from cell|
|cell activation|
|immune effector process|
|chemical homeostasis|
|secretion|
|lipid metabolic process|
|organonitrogen compound biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|homeostatic process|
|positive regulation of protein metabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|immune response|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|-1.87|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|-1.87|
|[[:results:exp121|Golgicide-A 2μM R03 exp121]]|-1.86|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|2.08|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|2.23|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|2.25|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17060
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.24 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LPCAT1 Expression in NALM6 Cells: 6.24'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>