LRAT [The Human Chemical-Genetic Interaction Map Project]

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======= LRAT =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LRAT
  * **<color #00a2e8>Official Name</color>**: lecithin retinol acyltransferase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9227|9227]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95237|O95237]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LRAT&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LRAT|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604863|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene localizes to the endoplasmic reticulum, where it catalyzes the esterification of all-trans-retinol into all-trans-retinyl ester. This reaction is an important step in vitamin A metabolism in the visual system. Mutations in this gene have been associated with early-onset severe retinal dystrophy and Leber congenital amaurosis 14. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Transfers the acyl group from the sn-1 position of phosphatidylcholine to all-trans retinol, producing all-trans retinyl esters. Retinyl esters are storage forms of vitamin A. LRAT plays a critical role in vision. It provides the all-trans retinyl ester substrates for the isomerohydrolase which processes the esters into 11-cis-retinol in the retinal pigment epithelium; due to a membrane-associated alcohol dehydrogenase, 11 cis-retinol is oxidized and converted into 11-cis-retinaldehyde which is the chromophore for rhodopsin and the cone photopigments. {ECO:0000269|PubMed:9920938}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|NC|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|phosphatidylcholine-retinol O-acyltransferase activity|
|O-palmitoyltransferase activity|
|lecithin:11-cis retinol acyltransferase activity|
|vitamin A metabolic process|
|retinol binding|
|response to vitamin A|
|transferase activity, transferring acyl groups|
|retinoic acid binding|
|multivesicular body|
|fat-soluble vitamin metabolic process|
|retinol metabolic process|
|rough endoplasmic reticulum|
|positive regulation of lipid transport|
|primary alcohol metabolic process|
|positive regulation of lipid localization|
|response to vitamin|
|response to leukemia inhibitory factor|
|cellular response to leukemia inhibitory factor|
|retinoid metabolic process|
|regulation of lipid transport|
|response to retinoic acid|
|diterpenoid metabolic process|
|terpenoid metabolic process|
|cellular hormone metabolic process|
|vitamin metabolic process|
|regulation of lipid localization|
|isoprenoid metabolic process|
|hormone metabolic process|
|response to nutrient|
|visual perception|
|sensory perception of light stimulus|
|alcohol metabolic process|
|response to acid chemical|
|organic hydroxy compound metabolic process|
|response to nutrient levels|
|response to extracellular stimulus|
|regulation of hormone levels|
|response to bacterium|
|perinuclear region of cytoplasm|
|response to lipid|
|endoplasmic reticulum membrane|
|cellular lipid metabolic process|
|sensory perception|
|positive regulation of transport|
|cellular response to cytokine stimulus|
|response to cytokine|
|lipid metabolic process|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|nervous system process|
|response to oxygen-containing compound|
|small molecule metabolic process|
|regulation of transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13677
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.33 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LRAT Expression in NALM6 Cells: 2.33'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>