LRIG2 [The Human Chemical-Genetic Interaction Map Project]

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======= LRIG2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LRIG2
  * **<color #00a2e8>Official Name</color>**: leucine rich repeats and immunoglobulin like domains 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9860|9860]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O94898|O94898]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LRIG2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LRIG2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608869|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a transmembrane protein containing leucine-rich repeats and immunoglobulin-like domains. The encoded protein promotes epidermal growth factor signalling, resulting in increased proliferation. Its expression in the cytoplasm of glioma cells is correlated with poor survival. Mutations in this gene can cause urofacial syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|LRR 4|
|I-set|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|intracellular vesicle|
|negative regulation of membrane protein ectodomain proteolysis|
|negative regulation of axon regeneration|
|negative regulation of neuron projection regeneration|
|positive regulation of protein localization to cell surface|
|regulation of platelet-derived growth factor receptor signaling pathway|
|regulation of membrane protein ectodomain proteolysis|
|regulation of axon regeneration|
|innervation|
|regulation of neuron projection regeneration|
|regulation of protein localization to cell surface|
|regulation of neuron migration|
|nerve development|
|negative regulation of response to wounding|
|growth cone|
|negative regulation of protein catabolic process|
|sensory perception of sound|
|negative regulation of neuron projection development|
|regulation of response to wounding|
|sensory perception of mechanical stimulus|
|negative regulation of cell projection organization|
|negative regulation of neuron differentiation|
|extracellular matrix|
|negative regulation of cellular catabolic process|
|negative regulation of neurogenesis|
|negative regulation of catabolic process|
|negative regulation of nervous system development|
|positive regulation of cellular protein localization|
|negative regulation of cell development|
|signaling receptor binding|
|negative regulation of proteolysis|
|negative regulation of response to external stimulus|
|neuronal cell body|
|regulation of protein catabolic process|
|regulation of neuron projection development|
|regulation of cellular protein localization|
|regulation of neuron differentiation|
|regulation of plasma membrane bounded cell projection organization|
|negative regulation of cellular component organization|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|regulation of proteolysis|
|regulation of cellular response to stress|
|regulation of neurogenesis|
|regulation of cellular catabolic process|
|regulation of cell migration|
|regulation of cell motility|
|regulation of cellular localization|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|sensory perception|
|regulation of locomotion|
|regulation of cellular component movement|
|regulation of catabolic process|
|regulation of protein localization|
|negative regulation of cellular protein metabolic process|
|regulation of response to external stimulus|
|negative regulation of protein metabolic process|
|negative regulation of multicellular organismal process|
|nervous system process|
|regulation of response to stress|
|generation of neurons|
|extracellular space|
|negative regulation of response to stimulus|
|neurogenesis|
|regulation of cell differentiation|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp519|RS-1 10μM R08 exp519]]|-2.51|
|[[:results:exp115|A-366 10μM R03 exp115]]|2.18|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.464|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10978
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.14 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LRIG2 Expression in NALM6 Cells: 6.14'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>