LRMP [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= LRMP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LRMP
  * **<color #00a2e8>Official Name</color>**: lymphoid restricted membrane protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4033|4033]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q12912|Q12912]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LRMP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LRMP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role in the delivery of peptides to major histocompatibility complex (MHC) class I molecules; this occurs in a transporter associated with antigen processing (TAP)-independent manner. May play a role in taste signal transduction via ITPR3. May play a role during fertilization in pronucleus congression and fusion.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|MRVI1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|azurophil granule membrane|
|vesicle fusion|
|organelle membrane fusion|
|vesicle targeting|
|organelle fusion|
|spindle pole|
|chromosome|
|membrane fusion|
|single fertilization|
|microtubule organizing center|
|fertilization|
|establishment of vesicle localization|
|nuclear envelope|
|vesicle localization|
|vesicle organization|
|establishment of organelle localization|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|organelle localization|
|myeloid leukocyte activation|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulated exocytosis|
|leukocyte mediated immunity|
|exocytosis|
|sexual reproduction|
|membrane organization|
|leukocyte activation|
|endoplasmic reticulum membrane|
|multi-organism reproductive process|
|secretion by cell|
|export from cell|
|cell activation|
|immune effector process|
|secretion|
|integral component of plasma membrane|
|reproductive process|
|reproduction|
|establishment of localization in cell|
|immune response|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp135|MS023 7μM R03 exp135]]|-2.36|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|-2.23|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|-2.2|
|[[:results:exp140|Nicotinate 1000μM R03 exp140]]|-2.13|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|-2.11|
|[[:results:exp121|Golgicide-A 2μM R03 exp121]]|-1.83|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|-1.8|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|1.71|
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|1.74|
|[[:results:exp292|Menadione 5μM R06 exp292]]|1.83|
|[[:results:exp10|CCCP 0.1μM R00 exp10]]|1.96|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|2.09|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|2.45|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|2.62|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:b:btk|BTK]]|0.409|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16736
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.61 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LRMP Expression in NALM6 Cells: 7.61'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>