LRP5L [The Human Chemical-Genetic Interaction Map Project]

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======= LRP5L =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LRP5L
  * **<color #00a2e8>Official Name</color>**: LDL receptor related protein 5 like
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=91355|91355]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/A4QPB2|A4QPB2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LRP5L&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LRP5L|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ldl recept b|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|retinal blood vessel morphogenesis|
|bone marrow development|
|retina vasculature morphogenesis in camera-type eye|
|retina vasculature development in camera-type eye|
|Wnt-activated receptor activity|
|osteoblast development|
|branching involved in mammary gland duct morphogenesis|
|gastrulation with mouth forming second|
|mammary gland duct morphogenesis|
|adipose tissue development|
|Wnt-protein binding|
|mammary gland morphogenesis|
|bone remodeling|
|regulation of insulin secretion involved in cellular response to glucose stimulus|
|mammary gland epithelium development|
|cholesterol homeostasis|
|sterol homeostasis|
|canonical Wnt signaling pathway|
|gland morphogenesis|
|tissue remodeling|
|bone morphogenesis|
|osteoblast differentiation|
|mammary gland development|
|branching morphogenesis of an epithelial tube|
|lipid homeostasis|
|retina development in camera-type eye|
|morphogenesis of a branching epithelium|
|gastrulation|
|morphogenesis of a branching structure|
|regulation of insulin secretion|
|bone development|
|receptor complex|
|regulation of peptide hormone secretion|
|anterior/posterior pattern specification|
|connective tissue development|
|skeletal system morphogenesis|
|ossification|
|regulation of hormone secretion|
|epithelial tube morphogenesis|
|camera-type eye development|
|regionalization|
|cell-cell signaling by wnt|
|Wnt signaling pathway|
|eye development|
|visual system development|
|sensory system development|
|blood vessel morphogenesis|
|gland development|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|morphogenesis of an epithelium|
|pattern specification process|
|regulation of protein secretion|
|blood vessel development|
|regulation of peptide secretion|
|skeletal system development|
|vasculature development|
|cardiovascular system development|
|regulation of hormone levels|
|sensory organ development|
|tissue morphogenesis|
|embryonic morphogenesis|
|hematopoietic or lymphoid organ development|
|immune system development|
|tube morphogenesis|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of secretion|
|tube development|
|circulatory system development|
|regulation of cellular localization|
|animal organ morphogenesis|
|embryo development|
|regulation of protein localization|
|chemical homeostasis|
|epithelium development|
|cell-cell signaling|
|positive regulation of transcription by RNA polymerase II|
|positive regulation of transcription, DNA-templated|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|cell development|
|positive regulation of RNA metabolic process|
|tissue development|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp332|Adefovir 20μM R07 exp332]]|-1.81|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4577
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.34 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LRP5L Expression in NALM6 Cells: 5.34'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>