LRRC8C [The Human Chemical-Genetic Interaction Map Project]

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======= LRRC8C =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LRRC8C
  * **<color #00a2e8>Official Name</color>**: leucine rich repeat containing 8 VRAC subunit C
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=84230|84230]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8TDW0|Q8TDW0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LRRC8C&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LRRC8C|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612889|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition. {ECO:0000269|PubMed:24790029, ECO:0000269|PubMed:26824658}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF3733|
|LRR 4|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|alkanesulfonate transport|
|taurine transport|
|volume-sensitive anion channel activity|
|ion channel complex|
|aspartate transmembrane transport|
|protein hexamerization|
|xenobiotic transport|
|C4-dicarboxylate transport|
|cellular response to osmotic stress|
|sulfur compound transport|
|acidic amino acid transport|
|amino acid transmembrane transport|
|response to osmotic stress|
|dicarboxylic acid transport|
|fat cell differentiation|
|amino acid transport|
|carboxylic acid transmembrane transport|
|organic acid transmembrane transport|
|inorganic anion transport|
|anion transmembrane transport|
|organic acid transport|
|carboxylic acid transport|
|cellular response to abiotic stimulus|
|cellular response to environmental stimulus|
|organic anion transport|
|protein complex oligomerization|
|anion transport|
|endoplasmic reticulum membrane|
|ion transmembrane transport|
|response to abiotic stimulus|
|transmembrane transport|
|ion transport|
|integral component of plasma membrane|
|protein-containing complex assembly|
|cellular response to stress|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp72|LB-100 4.1μM R02 exp72]]|-3.02|
|[[:results:exp210|LB-100 2μM R05 exp210]]|-2.52|
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|1.78|
|[[:results:exp11|CCCP 1μM R00 exp11]]|1.8|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|2.01|
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|2.03|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:l:lrrc8a|LRRC8A]]|0.407|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10172
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.07 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LRRC8C Expression in NALM6 Cells: 7.07'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>