LSM12 [The Human Chemical-Genetic Interaction Map Project]

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======= LSM12 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LSM12
  * **<color #00a2e8>Official Name</color>**: LSM12 homolog
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=124801|124801]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q3MHD2|Q3MHD2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LSM12&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LSM12|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611793|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='default' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|AD|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
No GO term information is available for this gene.
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|-1.91|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|-1.81|
|[[:results:exp71|KU-0063794 3.8μM R02 exp71]]|-1.71|
|[[:results:exp70|INK128 0.2μM R02 exp70]]|-1.7|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|1.87|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|2.24|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|2.3|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|2.56|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|2.67|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|3.29|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|3.34|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:atxn2l|ATXN2L]]|0.665|
|[[:human genes:f:flcn|FLCN]]|0.463|
|[[:human genes:c:cdk6|CDK6]]|0.455|
|[[:human genes:f:fnip1|FNIP1]]|0.448|
|[[:human genes:e:eif4g1|EIF4G1]]|0.428|
|[[:human genes:c:ccnc|CCNC]]|0.417|
|[[:human genes:m:med13|MED13]]|0.403|
|[[:human genes:f:fus|FUS]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 38/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|4/28|
|bone|0/26|
|breast|3/33|
|central nervous system|2/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|3/20|
|lung|3/75|
|lymphocyte|1/16|
|ovary|0/26|
|pancreas|1/24|
|peripheral nervous system|0/16|
|plasma cell|2/15|
|prostate|1/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2401
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.24 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LSM12 Expression in NALM6 Cells: 6.24'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>