LSM4 [The Human Chemical-Genetic Interaction Map Project]

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======= LSM4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LSM4
  * **<color #00a2e8>Official Name</color>**: LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=25804|25804]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y4Z0|Q9Y4Z0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LSM4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LSM4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607284|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Binds specifically to the 3'-terminal U-tract of U6 snRNA.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|LSM|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|PH domain binding|
|Lsm2-8 complex|
|U6 snRNP|
|U6 snRNA binding|
|cytoplasmic mRNA processing body assembly|
|exonucleolytic catabolism of deadenylated mRNA|
|U4/U6 x U5 tri-snRNP complex|
|nuclear-transcribed mRNA catabolic process, exonucleolytic|
|spliceosomal snRNP assembly|
|U2-type precatalytic spliceosome|
|nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|
|P-body|
|spliceosomal complex|
|nuclear-transcribed mRNA catabolic process|
|mRNA catabolic process|
|ribonucleoprotein complex assembly|
|ribonucleoprotein complex subunit organization|
|RNA catabolic process|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|RNA splicing, via transesterification reactions|
|neuron projection|
|nucleobase-containing compound catabolic process|
|RNA splicing|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|ribonucleoprotein complex biogenesis|
|mRNA processing|
|organic cyclic compound catabolic process|
|protein-containing complex|
|mRNA metabolic process|
|organelle assembly|
|cellular protein-containing complex assembly|
|RNA processing|
|cellular macromolecule catabolic process|
|macromolecule catabolic process|
|RNA binding|
|protein-containing complex assembly|
|RNA metabolic process|
|negative regulation of gene expression|
|organic substance catabolic process|
|cellular catabolic process|
|protein-containing complex subunit organization|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp277|Curcumin 6.5μM R06 exp277]]|-1.87|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|-1.85|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|-1.85|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 326/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|15/28|
|blood|7/28|
|bone|13/26|
|breast|9/33|
|central nervous system|33/56|
|cervix|3/4|
|colorectal|5/17|
|esophagus|8/13|
|fibroblast|1/1|
|gastric|9/16|
|kidney|6/21|
|liver|11/20|
|lung|26/75|
|lymphocyte|11/16|
|ovary|9/26|
|pancreas|11/24|
|peripheral nervous system|7/16|
|plasma cell|4/15|
|prostate|0/1|
|skin|9/24|
|soft tissue|7/9|
|thyroid|0/2|
|upper aerodigestive|8/22|
|urinary tract|11/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1234
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.02 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LSM4 Expression in NALM6 Cells: 6.02'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>