LSM5 [The Human Chemical-Genetic Interaction Map Project]

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======= LSM5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LSM5
  * **<color #00a2e8>Official Name</color>**: LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23658|23658]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y4Y9|Q9Y4Y9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LSM5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LSM5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607285|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA, thereby facilitating formation of the spliceosomal U4/U6 duplex formation in vitro.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|LSM|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Lsm1-7-Pat1 complex|
|Lsm2-8 complex|
|U6 snRNP|
|exonucleolytic catabolism of deadenylated mRNA|
|U4/U6 x U5 tri-snRNP complex|
|nuclear-transcribed mRNA catabolic process, exonucleolytic|
|U2-type precatalytic spliceosome|
|nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|
|nuclear-transcribed mRNA catabolic process|
|mRNA catabolic process|
|RNA catabolic process|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions|
|nucleobase-containing compound catabolic process|
|RNA splicing|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|mRNA processing|
|organic cyclic compound catabolic process|
|response to bacterium|
|mRNA metabolic process|
|RNA processing|
|cellular macromolecule catabolic process|
|macromolecule catabolic process|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|RNA binding|
|RNA metabolic process|
|negative regulation of gene expression|
|organic substance catabolic process|
|cellular catabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|-1.93|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 61/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|3/28|
|blood|0/28|
|bone|6/26|
|breast|5/33|
|central nervous system|8/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|2/21|
|liver|2/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|3/26|
|pancreas|0/24|
|peripheral nervous system|3/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|3/9|
|thyroid|0/2|
|upper aerodigestive|2/22|
|urinary tract|3/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4056
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.54 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LSM5 Expression in NALM6 Cells: 5.54'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>