LSMD1 [The Human Chemical-Genetic Interaction Map Project]

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======= LSMD1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: N/AA38
  * **<color #00a2e8>Official Name</color>**: N-alpha-acetyltransferase 38, NatC auxiliary subunit
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=84316|84316]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BRA0|Q9BRA0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LSMD1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LSMD1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617990|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues. {ECO:0000269|PubMed:19398576}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|LSM|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|NatC complex|
|polysome|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|negative regulation of cell death|
|regulation of apoptotic process|
|regulation of programmed cell death|
|regulation of cell death|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp442|Ibrutinib 10μM R08 exp442]]|-2.39|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-2.2|
|[[:results:exp480|ETC-159 50μM R08 exp480]]|-1.94|
|[[:results:exp344|Chlorpromazine 10μM R07 exp344]]|-1.91|
|[[:results:exp483|FTY720 3μM R08 exp483]]|-1.89|
|[[:results:exp530|Thioridazine 5μM R08 exp530]]|-1.84|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:naa35|NAA35]]|0.498|
|[[:human genes:d:dpagt1|DPAGT1]]|0.487|
|[[:human genes:r:rptor|RPTOR]]|0.487|
|[[:human genes:m:med16|MED16]]|0.486|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.485|
|[[:human genes:r:rnmt|RNMT]]|0.483|
|[[:human genes:w:wdr24|WDR24]]|0.477|
|[[:human genes:e:eif4e|EIF4E]]|0.475|
|[[:human genes:t:thg1l|THG1L]]|0.462|
|[[:human genes:c:ctdnep1|CTDNEP1]]|0.458|
|[[:human genes:g:gfpt1|GFPT1]]|0.452|
|[[:human genes:t:tti2|TTI2]]|0.451|
|[[:human genes:g:gmppb|GMPPB]]|0.447|
|[[:human genes:t:tmed10|TMED10]]|0.446|
|[[:human genes:a:arl1|ARL1]]|0.445|
|[[:human genes:d:dolk|DOLK]]|0.442|
|[[:human genes:m:mapk14|MAPK14]]|0.44|
|[[:human genes:u:uba3|UBA3]]|0.439|
|[[:human genes:c:ccdc101|CCDC101]]|0.438|
|[[:human genes:c:cbfb|CBFB]]|0.436|
|[[:human genes:s:srp72|SRP72]]|0.435|
|[[:human genes:m:mllt1|MLLT1]]|0.434|
|[[:human genes:a:alg1|ALG1]]|0.427|
|[[:human genes:c:chka|CHKA]]|0.426|
|[[:human genes:m:med23|MED23]]|0.426|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.424|
|[[:human genes:u:ube2g2|UBE2G2]]|0.424|
|[[:human genes:m:mtor|MTOR]]|0.422|
|[[:human genes:a:alg5|ALG5]]|0.421|
|[[:human genes:a:aars|AARS]]|0.421|
|[[:human genes:p:pmm2|PMM2]]|0.42|
|[[:human genes:l:lamtor5|LAMTOR5]]|0.42|
|[[:human genes:p:pelo|PELO]]|0.419|
|[[:human genes:m:med4|MED4]]|0.417|
|[[:human genes:f:fli1|FLI1]]|0.416|
|[[:human genes:t:tmem41b|TMEM41B]]|0.416|
|[[:human genes:d:dnajc3|DNAJC3]]|0.415|
|[[:human genes:r:rtcb|RTCB]]|0.415|
|[[:human genes:o:oraov1|ORAOV1]]|0.413|
|[[:human genes:d:dohh|DOHH]]|0.412|
|[[:human genes:g:gnb1l|GNB1L]]|0.412|
|[[:human genes:m:meaf6|MEAF6]]|0.412|
|[[:human genes:e:eny2|ENY2]]|0.411|
|[[:human genes:n:nhlrc2|NHLRC2]]|0.407|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.404|
|[[:human genes:h:hars|HARS]]|0.402|
|[[:human genes:s:smarcd1|SMARCD1]]|0.401|
|[[:human genes:b:brd9|BRD9]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5231
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.09 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LSMD1 Expression in NALM6 Cells: 5.09'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>