LYPD8 [The Human Chemical-Genetic Interaction Map Project]

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======= LYPD8 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LYPD8
  * **<color #00a2e8>Official Name</color>**: LY6/PLAUR domain containing 8
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=646627|646627]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6UX82|Q6UX82]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LYPD8&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LYPD8|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617067|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Secreted protein specifically required to prevent invasion of Gram-negative bacteria in the inner mucus layer of the colon epithelium, a portion of the large intestine which is free of commensal microbiota. Prevents invasion of flagellated microbiota by binding to the flagellum of bacteria, such as P.mirabilis, thereby inhibiting bacterial motility in the intestinal lumen. Segregation of intestinal bacteria and epithelial cells in the colon is required to preserve intestinal homeostasis. {ECO:0000250|UniProtKB:Q9D7S0}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|defense response to Gram-negative bacterium|
|anchored component of membrane|
|defense response to bacterium|
|response to bacterium|
|defense response to other organism|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|extracellular space|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|-2.21|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|-2.13|
|[[:results:exp538|ZLN024 50μM R08 exp538]]|-1.78|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|-1.73|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|-1.71|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|-1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15908
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.9 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LYPD8 Expression in NALM6 Cells: 0.9'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>