MAD1L1 [The Human Chemical-Genetic Interaction Map Project]

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======= MAD1L1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MAD1L1
  * **<color #00a2e8>Official Name</color>**: mitotic arrest deficient 1 like 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8379|8379]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y6D9|Q9Y6D9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MAD1L1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MAD1L1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602686|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  MAD1L1 is a component of the mitotic spindle-assembly checkpoint that prevents the onset of anaphase until all chromosome are properly aligned at the metaphase plate. MAD1L1 functions as a homodimer and interacts with MAD2L1. MAD1L1 may play a role in cell cycle control and tumor suppression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. May recruit MAD2L1 to unattached kinetochores. Has a role in the correct positioning of the septum. Required for anchoring MAD2L1 to the nuclear periphery. Binds to the TERT promoter and represses telomerase expression, possibly by interfering with MYC binding. {ECO:0000269|PubMed:10049595, ECO:0000269|PubMed:12837246, ECO:0000269|PubMed:20133940}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|MAD|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|kinetochore binding|
|regulation of metaphase plate congression|
|attachment of mitotic spindle microtubules to kinetochore|
|nuclear pore nuclear basket|
|attachment of spindle microtubules to kinetochore|
|mitotic spindle assembly checkpoint|
|spindle checkpoint|
|spindle assembly checkpoint|
|mitotic spindle checkpoint|
|negative regulation of mitotic metaphase/anaphase transition|
|negative regulation of metaphase/anaphase transition of cell cycle|
|mitotic spindle pole|
|negative regulation of mitotic sister chromatid separation|
|negative regulation of chromosome separation|
|negative regulation of mitotic sister chromatid segregation|
|negative regulation of sister chromatid segregation|
|negative regulation of chromosome segregation|
|negative regulation of mitotic nuclear division|
|thymus development|
|mitotic metaphase plate congression|
|negative regulation of nuclear division|
|regulation of mitotic metaphase/anaphase transition|
|regulation of metaphase/anaphase transition of cell cycle|
|metaphase plate congression|
|regulation of mitotic sister chromatid separation|
|negative regulation of T cell proliferation|
|regulation of chromosome separation|
|regulation of mitotic sister chromatid segregation|
|establishment of chromosome localization|
|chromosome localization|
|negative regulation of mononuclear cell proliferation|
|negative regulation of lymphocyte proliferation|
|mitotic spindle|
|negative regulation of leukocyte proliferation|
|regulation of sister chromatid segregation|
|kinetochore|
|condensed chromosome kinetochore|
|regulation of chromosome segregation|
|mitotic sister chromatid segregation|
|negative regulation of T cell activation|
|spindle|
|negative regulation of leukocyte cell-cell adhesion|
|negative regulation of chromosome organization|
|sister chromatid segregation|
|negative regulation of lymphocyte activation|
|mitotic nuclear division|
|mitotic cell cycle checkpoint|
|regulation of T cell proliferation|
|regulation of mitotic nuclear division|
|negative regulation of cell-cell adhesion|
|negative regulation of leukocyte activation|
|nuclear envelope|
|regulation of nuclear division|
|cell cycle checkpoint|
|negative regulation of cell activation|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|negative regulation of mitotic cell cycle phase transition|
|nuclear chromosome segregation|
|regulation of leukocyte proliferation|
|negative regulation of cell cycle phase transition|
|negative regulation of cell adhesion|
|chromosome segregation|
|nuclear division|
|regulation of leukocyte cell-cell adhesion|
|negative regulation of mitotic cell cycle|
|organelle fission|
|regulation of T cell activation|
|negative regulation of cell cycle process|
|regulation of chromosome organization|
|establishment of organelle localization|
|negative regulation of organelle organization|
|regulation of cell-cell adhesion|
|gland development|
|regulation of mitotic cell cycle phase transition|
|negative regulation of immune system process|
|regulation of cell cycle phase transition|
|centrosome|
|cell division|
|regulation of lymphocyte activation|
|negative regulation of cell cycle|
|organelle localization|
|mitotic cell cycle process|
|regulation of leukocyte activation|
|hematopoietic or lymphoid organ development|
|regulation of mitotic cell cycle|
|regulation of cell activation|
|immune system development|
|negative regulation of cell population proliferation|
|regulation of cell adhesion|
|mitotic cell cycle|
|negative regulation of cellular component organization|
|regulation of cell cycle process|
|regulation of cellular localization|
|cell cycle process|
|chromosome organization|
|identical protein binding|
|regulation of cell cycle|
|regulation of organelle organization|
|cell cycle|
|regulation of cell population proliferation|
|regulation of immune system process|
|establishment of localization in cell|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp134|MS023 2μM R03 exp134]]|-1.87|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|-1.7|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|1.7|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|1.76|
|[[:results:exp125|GSK461364A 0.005μM R03 exp125]]|2.03|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|2.12|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|2.64|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|2.87|
|[[:results:exp17|DABN 20μM R00 exp17]]|3.33|
|[[:results:exp108|Vinblastine 0.2μM R03 exp108]]|4.41|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|4.61|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|5.1|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|5.2|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|5.35|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|5.43|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|5.56|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|5.67|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|5.84|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|6.09|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|6.31|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|6.44|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:mad2l1|MAD2L1]]|0.863|
|[[:human genes:z:zw10|ZW10]]|0.807|
|[[:human genes:r:rbm14|RBM14]]|0.802|
|[[:human genes:b:bub1b|BUB1B]]|0.801|
|[[:human genes:b:bub3|BUB3]]|0.801|
|[[:human genes:k:kntc1|KNTC1]]|0.778|
|[[:human genes:t:trip13|TRIP13]]|0.761|
|[[:human genes:z:zwilch|ZWILCH]]|0.721|
|[[:human genes:m:mad2l1bp|MAD2L1BP]]|0.683|
|[[:human genes:c:cdc20|CDC20]]|0.535|
|[[:human genes:f:fntb|FNTB]]|0.506|
|[[:human genes:f:fnta|FNTA]]|0.487|
|[[:human genes:d:dbr1|DBR1]]|0.485|
|[[:human genes:m:med16|MED16]]|0.441|
|[[:human genes:p:pelo|PELO]]|0.432|
|[[:human genes:c:cenpe|CENPE]]|0.421|
|[[:human genes:h:hbs1l|HBS1L]]|0.411|
|[[:human genes:d:ddx20|DDX20]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 728
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.81 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MAD1L1 Expression in NALM6 Cells: 5.81'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>