MAD2L2 [The Human Chemical-Genetic Interaction Map Project]

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======= MAD2L2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MAD2L2
  * **<color #00a2e8>Official Name</color>**: mitotic arrest deficient 2 like 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10459|10459]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UI95|Q9UI95]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MAD2L2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MAD2L2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604094|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. The encoded protein, which is similar to MAD2L1, is capable of interacting with ADAM9, ADAM15, REV1, and REV3 proteins. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Adapter protein able to interact with different proteins and involved in different biological processes. Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit REV3L and the inserter polymerase REV1, thereby mediating the second polymerase switching in translesion DNA synthesis. Translesion DNA synthesis releases the replication blockade of replicative polymerases, stalled in presence of DNA lesions. May also regulate another aspect of cellular response to DNA damage through regulation of the JNK-mediated phosphorylation and activation of the transcriptional activator ELK1. Inhibits the FZR1- and probably CDC20-mediated activation of the anaphase promoting complex APC thereby regulating progression through the cell cycle. Regulates TCF7L2-mediated gene transcription and may play a role in epithelial-mesenchymal transdifferentiation. {ECO:0000269|PubMed:11459825, ECO:0000269|PubMed:11459826, ECO:0000269|PubMed:17296730, ECO:0000269|PubMed:17719540, ECO:0000269|PubMed:19443654}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|HORMA|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|zeta DNA polymerase complex|
|JUN kinase binding|
|negative regulation of cell-cell adhesion mediated by cadherin|
|negative regulation of ubiquitin protein ligase activity|
|negative regulation of transcription by competitive promoter binding|
|positive regulation of double-strand break repair via nonhomologous end joining|
|DNA damage response, signal transduction resulting in transcription|
|negative regulation of ubiquitin-protein transferase activity|
|regulation of cell-cell adhesion mediated by cadherin|
|negative regulation of double-strand break repair via homologous recombination|
|error-prone translesion synthesis|
|anaphase-promoting complex|
|negative regulation of transcription regulatory region DNA binding|
|regulation of ubiquitin protein ligase activity|
|mitotic spindle checkpoint|
|spindle assembly checkpoint|
|spindle checkpoint|
|mitotic spindle assembly checkpoint|
|negative regulation of mitotic metaphase/anaphase transition|
|regulation of double-strand break repair via nonhomologous end joining|
|positive regulation of isotype switching|
|negative regulation of metaphase/anaphase transition of cell cycle|
|negative regulation of epithelial to mesenchymal transition|
|negative regulation of mitotic sister chromatid separation|
|negative regulation of chromosome separation|
|negative regulation of mitotic sister chromatid segregation|
|positive regulation of double-strand break repair|
|negative regulation of double-strand break repair|
|negative regulation of sister chromatid segregation|
|negative regulation of DNA repair|
|negative regulation of chromosome segregation|
|regulation of isotype switching|
|positive regulation of immunoglobulin mediated immune response|
|positive regulation of B cell mediated immunity|
|positive regulation of DNA recombination|
|negative regulation of mitotic nuclear division|
|translesion synthesis|
|positive regulation of immunoglobulin production|
|negative regulation of DNA recombination|
|regulation of double-strand break repair via homologous recombination|
|negative regulation of nuclear division|
|regulation of mitotic metaphase/anaphase transition|
|DNA synthesis involved in DNA repair|
|regulation of ubiquitin-protein transferase activity|
|regulation of immunoglobulin mediated immune response|
|regulation of B cell mediated immunity|
|regulation of transcription regulatory region DNA binding|
|regulation of metaphase/anaphase transition of cell cycle|
|RNA polymerase II activating transcription factor binding|
|postreplication repair|
|negative regulation of DNA binding|
|regulation of mitotic sister chromatid separation|
|site of double-strand break|
|regulation of chromosome separation|
|regulation of immunoglobulin production|
|positive regulation of DNA repair|
|regulation of mitotic sister chromatid segregation|
|negative regulation of protein ubiquitination|
|regulation of double-strand break repair|
|negative regulation of response to DNA damage stimulus|
|regulation of sister chromatid segregation|
|negative regulation of protein modification by small protein conjugation or removal|
|regulation of epithelial to mesenchymal transition|
|positive regulation of production of molecular mediator of immune response|
|positive regulation of response to DNA damage stimulus|
|positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|regulation of chromosome segregation|
|signal transduction in response to DNA damage|
|regulation of DNA recombination|
|positive regulation of peptidyl-serine phosphorylation|
|positive regulation of lymphocyte mediated immunity|
|positive regulation of adaptive immune response|
|DNA biosynthetic process|
|spindle|
|negative regulation of DNA metabolic process|
|chromosome|
|regulation of DNA repair|
|regulation of DNA binding|
|positive regulation of leukocyte mediated immunity|
|negative regulation of protein catabolic process|
|negative regulation of chromosome organization|
|regulation of peptidyl-serine phosphorylation|
|regulation of production of molecular mediator of immune response|
|regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|regulation of lymphocyte mediated immunity|
|mitotic cell cycle checkpoint|
|negative regulation of DNA-binding transcription factor activity|
|regulation of adaptive immune response|
|positive regulation of B cell activation|
|regulation of mitotic nuclear division|
|negative regulation of binding|
|negative regulation of cell-cell adhesion|
|negative regulation of canonical Wnt signaling pathway|
|double-strand break repair|
|regulation of nuclear division|
|positive regulation of DNA metabolic process|
|cell cycle checkpoint|
|regulation of protein ubiquitination|
|regulation of leukocyte mediated immunity|
|regulation of B cell activation|
|negative regulation of Wnt signaling pathway|
|negative regulation of mitotic cell cycle phase transition|
|regulation of response to DNA damage stimulus|
|positive regulation of immune effector process|
|regulation of protein modification by small protein conjugation or removal|
|negative regulation of cell cycle phase transition|
|actin filament organization|
|negative regulation of cell adhesion|
|negative regulation of transferase activity|
|regulation of canonical Wnt signaling pathway|
|negative regulation of mitotic cell cycle|
|negative regulation of catabolic process|
|negative regulation of cell cycle process|
|regulation of chromosome organization|
|regulation of DNA metabolic process|
|positive regulation of lymphocyte activation|
|regulation of Wnt signaling pathway|
|negative regulation of organelle organization|
|regulation of binding|
|regulation of protein catabolic process|
|regulation of cell-cell adhesion|
|positive regulation of leukocyte activation|
|regulation of mitotic cell cycle phase transition|
|positive regulation of cell activation|
|regulation of cell growth|
|regulation of DNA-binding transcription factor activity|
|regulation of cell cycle phase transition|
|supramolecular fiber organization|
|regulation of immune effector process|
|cell division|
|actin cytoskeleton organization|
|DNA repair|
|regulation of lymphocyte activation|
|actin filament-based process|
|negative regulation of cell cycle|
|negative regulation of protein modification process|
|mitotic cell cycle process|
|regulation of leukocyte activation|
|regulation of mitotic cell cycle|
|regulation of cell activation|
|regulation of growth|
|regulation of cell adhesion|
|mitotic cell cycle|
|negative regulation of cellular component organization|
|negative regulation of cell differentiation|
|regulation of cellular response to stress|
|DNA metabolic process|
|regulation of cell cycle process|
|cellular response to DNA damage stimulus|
|negative regulation of catalytic activity|
|nucleolus|
|negative regulation of transcription by RNA polymerase II|
|positive regulation of immune response|
|negative regulation of developmental process|
|regulation of transferase activity|
|regulation of catabolic process|
|cell cycle process|
|positive regulation of protein phosphorylation|
|negative regulation of cellular protein metabolic process|
|positive regulation of phosphorylation|
|nucleobase-containing compound biosynthetic process|
|negative regulation of protein metabolic process|
|cytoskeleton organization|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|negative regulation of molecular function|
|positive regulation of immune system process|
|regulation of immune response|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of protein modification process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|regulation of organelle organization|
|organic cyclic compound biosynthetic process|
|negative regulation of RNA metabolic process|
|cell cycle|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|regulation of immune system process|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|macromolecule biosynthetic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|regulation of protein modification process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp273|Cisplatin 0.35μM R06 exp273]]|-3.19|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|-2.89|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|-2.57|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|-2.47|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|-2.43|
|[[:results:exp274|Citral 50μM R06 exp274]]|-2.31|
|[[:results:exp100|NFN1 1μM R03 exp100]]|-2.14|
|[[:results:exp99|NFN1 0.4μM R03 exp99]]|-2.07|
|[[:results:exp299|Talazoparib 0.006μM R06 exp299]]|-1.91|
|[[:results:exp332|Adefovir 20μM R07 exp332]]|-1.8|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|-1.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:mcm9|MCM9]]|0.514|
|[[:human genes:s:sfr1|SFR1]]|0.478|
|[[:human genes:r:rad51b|RAD51B]]|0.438|
|[[:human genes:s:swi5|SWI5]]|0.433|
|[[:human genes:r:rad51d|RAD51D]]|0.412|
|[[:human genes:m:mcm8|MCM8]]|0.406|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 622/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|24/28|
|blood|23/28|
|bone|24/26|
|breast|29/33|
|central nervous system|51/56|
|cervix|4/4|
|colorectal|15/17|
|esophagus|12/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|15/21|
|liver|17/20|
|lung|64/75|
|lymphocyte|15/16|
|ovary|19/26|
|pancreas|19/24|
|peripheral nervous system|15/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|13/24|
|soft tissue|8/9|
|thyroid|2/2|
|upper aerodigestive|20/22|
|urinary tract|22/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 867
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.37 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MAD2L2 Expression in NALM6 Cells: 6.37'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>