MAGI2 [The Human Chemical-Genetic Interaction Map Project]

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======= MAGI2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MAGI2
  * **<color #00a2e8>Official Name</color>**: membrane associated guanylate kinase, WW and PDZ domain containing 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9863|9863]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q86UL8|Q86UL8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MAGI2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MAGI2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606382|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene interacts with atrophin-1. Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy. This encoded protein is characterized by two WW domains, a guanylate kinase-like domain, and multiple PDZ domains. It has structural similarity to the membrane-associated guanylate kinase homologue (MAGUK) family. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Guanylate kin|
|PDZ|
|WW|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|type II activin receptor binding|
|beta-1 adrenergic receptor binding|
|neuroligin clustering involved in postsynaptic membrane assembly|
|planar cell polarity pathway involved in axis elongation|
|positive regulation of synaptic vesicle clustering|
|regulation of synaptic vesicle clustering|
|slit diaphragm|
|glomerular visceral epithelial cell development|
|glomerular epithelial cell development|
|negative regulation of activin receptor signaling pathway|
|nerve growth factor signaling pathway|
|postsynaptic membrane assembly|
|renal filtration cell differentiation|
|glomerular visceral epithelial cell differentiation|
|mitotic cell cycle arrest|
|glomerular epithelial cell differentiation|
|postsynapse assembly|
|glomerular epithelium development|
|positive regulation of phosphoprotein phosphatase activity|
|receptor signaling complex adaptor activity|
|regulation of activin receptor signaling pathway|
|positive regulation of receptor internalization|
|axis elongation|
|neurotrophin signaling pathway|
|postsynaptic membrane organization|
|epithelial cell differentiation involved in kidney development|
|positive regulation of phosphatase activity|
|membrane assembly|
|membrane biogenesis|
|cell differentiation involved in kidney development|
|positive regulation of protein dephosphorylation|
|negative regulation of protein kinase B signaling|
|receptor clustering|
|cellular response to nerve growth factor stimulus|
|phosphatase binding|
|glomerulus development|
|positive regulation of receptor-mediated endocytosis|
|response to nerve growth factor|
|SMAD binding|
|regulation of receptor internalization|
|SMAD protein signal transduction|
|positive regulation of dephosphorylation|
|localization within membrane|
|postsynapse organization|
|synapse assembly|
|nephron epithelium development|
|Wnt signaling pathway, planar cell polarity pathway|
|regulation of receptor-mediated endocytosis|
|positive regulation of endocytosis|
|protein heterooligomerization|
|regulation of establishment of planar polarity|
|regulation of synaptic vesicle cycle|
|developmental growth involved in morphogenesis|
|negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|regulation of phosphoprotein phosphatase activity|
|bicellular tight junction|
|nephron development|
|late endosome|
|kidney epithelium development|
|non-canonical Wnt signaling pathway|
|regulation of protein dephosphorylation|
|cell cycle arrest|
|cell-cell junction|
|regulation of phosphatase activity|
|regulation of morphogenesis of an epithelium|
|epithelial cell development|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|regulation of endocytosis|
|regulation of dephosphorylation|
|regulation of protein kinase B signaling|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|postsynaptic density|
|regulation of animal organ morphogenesis|
|negative regulation of cell migration|
|kidney development|
|synapse|
|synapse organization|
|negative regulation of cell motility|
|positive regulation of neuron projection development|
|renal system development|
|negative regulation of mitotic cell cycle|
|negative regulation of cellular component movement|
|urogenital system development|
|negative regulation of locomotion|
|Wnt signaling pathway|
|cell-cell signaling by wnt|
|positive regulation of neuron differentiation|
|positive regulation of cell projection organization|
|developmental growth|
|growth|
|dendrite|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|positive regulation of neurogenesis|
|protein localization to membrane|
|regulation of neuron projection development|
|cellular response to growth factor stimulus|
|negative regulation of intracellular signal transduction|
|protein complex oligomerization|
|response to growth factor|
|positive regulation of nervous system development|
|positive regulation of cell development|
|regulation of vesicle-mediated transport|
|negative regulation of cell cycle|
|protein-containing complex|
|regulation of mitotic cell cycle|
|regulation of neuron differentiation|
|negative regulation of cell population proliferation|
|epithelial cell differentiation|
|regulation of plasma membrane bounded cell projection organization|
|perinuclear region of cytoplasm|
|regulation of cell projection organization|
|enzyme linked receptor protein signaling pathway|
|positive regulation of hydrolase activity|
|regulation of neurogenesis|
|regulation of cell migration|
|membrane organization|
|regulation of cell motility|
|regulation of cellular localization|
|regulation of nervous system development|
|regulation of cell development|
|positive regulation of cell differentiation|
|regulation of locomotion|
|positive regulation of transport|
|regulation of cellular component movement|
|cell cycle process|
|regulation of anatomical structure morphogenesis|
|epithelium development|
|cell-cell signaling|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|regulation of cell cycle|
|positive regulation of cellular component organization|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|cell cycle|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|positive regulation of catalytic activity|
|response to endogenous stimulus|
|generation of neurons|
|protein-containing complex assembly|
|cellular protein localization|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|neurogenesis|
|cell development|
|positive regulation of signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp473|Cincreasin 100μM R08 exp473]]|-1.85|
|[[:results:exp533|TNF-alpha 44ng/ml R08 exp533]]|-1.85|
|[[:results:exp336|Asunaprenir 3μM R07 exp336]]|-1.84|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6947
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.84 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MAGI2 Expression in NALM6 Cells: 1.84'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>