MALSU1 [The Human Chemical-Genetic Interaction Map Project]

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======= MALSU1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MALSU1
  * **<color #00a2e8>Official Name</color>**: mitochondrial assembly of ribosomal large subunit 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=115416|115416]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96EH3|Q96EH3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MALSU1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MALSU1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614624|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May function as a ribosomal silencing factor. Addition to isolated mitochondrial ribosomal subunits partially inhibits translation. Interacts with mitochondrial ribosomal protein L14 (MRPL14), probably blocking formation of intersubunit bridge B8, preventing association of the 28S and 39S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. May also participate in the assembly and/or regulation of the stability of the large subunit of the mitochondrial ribosome. {ECO:0000269|PubMed:22238376}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF143|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of mitochondrial translation|
|negative regulation of ribosome biogenesis|
|ribosomal large subunit binding|
|regulation of ribosome biogenesis|
|regulation of mitochondrial translation|
|regulation of mitochondrial gene expression|
|mitochondrial large ribosomal subunit|
|ribosomal large subunit biogenesis|
|negative regulation of translation|
|negative regulation of cellular amide metabolic process|
|ribosome biogenesis|
|regulation of translation|
|regulation of cellular amide metabolic process|
|ribonucleoprotein complex biogenesis|
|posttranscriptional regulation of gene expression|
|regulation of cellular component biogenesis|
|negative regulation of cellular protein metabolic process|
|negative regulation of protein metabolic process|
|mitochondrion|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|negative regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|1.7|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|1.7|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|1.97|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|2.06|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|2.07|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|2.19|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|2.38|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:pet117|PET117]]|0.607|
|[[:human genes:c:coa3|COA3]]|0.595|
|[[:human genes:f:ftsj2|FTSJ2]]|0.584|
|[[:human genes:r:rpusd3|RPUSD3]]|0.572|
|[[:human genes:p:pet112|PET112]]|0.562|
|[[:human genes:n:nars2|NARS2]]|0.56|
|[[:human genes:l:lars2|LARS2]]|0.553|
|[[:human genes:m:mrpl49|MRPL49]]|0.55|
|[[:human genes:m:mtif2|MTIF2]]|0.545|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.543|
|[[:human genes:g:gtpbp8|GTPBP8]]|0.542|
|[[:human genes:s:selrc1|SELRC1]]|0.541|
|[[:human genes:m:mrps16|MRPS16]]|0.54|
|[[:human genes:m:mto1|MTO1]]|0.537|
|[[:human genes:a:acad9|ACAD9]]|0.536|
|[[:human genes:c:chchd1|CHCHD1]]|0.535|
|[[:human genes:c:cars2|CARS2]]|0.534|
|[[:human genes:n:ndufb11|NDUFB11]]|0.533|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.53|
|[[:human genes:m:mrps21|MRPS21]]|0.53|
|[[:human genes:g:grsf1|GRSF1]]|0.529|
|[[:human genes:n:nsun4|NSUN4]]|0.527|
|[[:human genes:c:cox11|COX11]]|0.525|
|[[:human genes:m:mtg2|MTG2]]|0.521|
|[[:human genes:a:aars2|AARS2]]|0.52|
|[[:human genes:m:mrpl45|MRPL45]]|0.52|
|[[:human genes:p:pars2|PARS2]]|0.519|
|[[:human genes:q:qrsl1|QRSL1]]|0.518|
|[[:human genes:t:tfb1m|TFB1M]]|0.518|
|[[:human genes:g:gfm2|GFM2]]|0.517|
|[[:human genes:r:rbfa|RBFA]]|0.513|
|[[:human genes:m:mrps27|MRPS27]]|0.507|
|[[:human genes:n:nubpl|NUBPL]]|0.506|
|[[:human genes:t:tars2|TARS2]]|0.505|
|[[:human genes:e:ecsit|ECSIT]]|0.503|
|[[:human genes:n:ndufs2|NDUFS2]]|0.501|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.5|
|[[:human genes:m:mcat|MCAT]]|0.5|
|[[:human genes:d:ddx28|DDX28]]|0.5|
|[[:human genes:f:fastkd2|FASTKD2]]|0.499|
|[[:human genes:p:pde12|PDE12]]|0.498|
|[[:human genes:g:gfm1|GFM1]]|0.497|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.495|
|[[:human genes:s:ssbp1|SSBP1]]|0.492|
|[[:human genes:p:polg2|POLG2]]|0.492|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.491|
|[[:human genes:v:vars2|VARS2]]|0.491|
|[[:human genes:m:mrpl4|MRPL4]]|0.49|
|[[:human genes:n:ndufa3|NDUFA3]]|0.489|
|[[:human genes:m:mterfd1|MTERFD1]]|0.488|
|[[:human genes:e:eral1|ERAL1]]|0.487|
|[[:human genes:h:hmgxb3|HMGXB3]]|0.483|
|[[:human genes:n:ndufa1|NDUFA1]]|0.483|
|[[:human genes:x:xpnpep3|XPNPEP3]]|0.481|
|[[:human genes:m:mrpl43|MRPL43]]|0.48|
|[[:human genes:y:yars2|YARS2]]|0.479|
|[[:human genes:n:ndufaf5|NDUFAF5]]|0.479|
|[[:human genes:m:mettl17|METTL17]]|0.478|
|[[:human genes:m:mrps6|MRPS6]]|0.477|
|[[:human genes:n:ndufb10|NDUFB10]]|0.476|
|[[:human genes:r:rpusd4|RPUSD4]]|0.476|
|[[:human genes:p:polg|POLG]]|0.474|
|[[:human genes:m:mrpl1|MRPL1]]|0.474|
|[[:human genes:m:mrpl53|MRPL53]]|0.474|
|[[:human genes:m:mrpl21|MRPL21]]|0.473|
|[[:human genes:m:mrps12|MRPS12]]|0.472|
|[[:human genes:m:mars2|MARS2]]|0.47|
|[[:human genes:n:ndufb6|NDUFB6]]|0.47|
|[[:human genes:m:mrps34|MRPS34]]|0.468|
|[[:human genes:d:dap3|DAP3]]|0.466|
|[[:human genes:d:dars2|DARS2]]|0.465|
|[[:human genes:p:ptcd3|PTCD3]]|0.464|
|[[:human genes:c:c1qbp|C1QBP]]|0.464|
|[[:human genes:c:coa6|COA6]]|0.464|
|[[:human genes:n:ndufs5|NDUFS5]]|0.463|
|[[:human genes:n:ndufa10|NDUFA10]]|0.463|
|[[:human genes:m:mrps5|MRPS5]]|0.461|
|[[:human genes:r:rars2|RARS2]]|0.46|
|[[:human genes:t:tmem261|TMEM261]]|0.46|
|[[:human genes:m:mrps26|MRPS26]]|0.459|
|[[:human genes:n:ndufv2|NDUFV2]]|0.459|
|[[:human genes:m:mrpl23|MRPL23]]|0.457|
|[[:human genes:n:ndufaf6|NDUFAF6]]|0.456|
|[[:human genes:n:ndufa2|NDUFA2]]|0.455|
|[[:human genes:m:mrps35|MRPS35]]|0.454|
|[[:human genes:r:rnmtl1|RNMTL1]]|0.453|
|[[:human genes:e:ears2|EARS2]]|0.451|
|[[:human genes:s:sco2|SCO2]]|0.45|
|[[:human genes:p:polrmt|POLRMT]]|0.449|
|[[:human genes:m:mrps25|MRPS25]]|0.449|
|[[:human genes:n:ndufc2|NDUFC2]]|0.449|
|[[:human genes:p:prepl|PREPL]]|0.449|
|[[:human genes:m:mterfd2|MTERFD2]]|0.448|
|[[:human genes:m:mtg1|MTG1]]|0.447|
|[[:human genes:m:mrpl44|MRPL44]]|0.446|
|[[:human genes:c:c12orf65|C12orf65]]|0.446|
|[[:human genes:n:ndufc1|NDUFC1]]|0.445|
|[[:human genes:t:tomm20|TOMM20]]|0.445|
|[[:human genes:a:aifm1|AIFM1]]|0.444|
|[[:human genes:m:mrpl3|MRPL3]]|0.443|
|[[:human genes:m:mrpl28|MRPL28]]|0.439|
|[[:human genes:m:mrpl47|MRPL47]]|0.438|
|[[:human genes:i:ict1|ICT1]]|0.437|
|[[:human genes:m:mrps14|MRPS14]]|0.437|
|[[:human genes:h:hars2|HARS2]]|0.437|
|[[:human genes:r:rmnd1|RMND1]]|0.436|
|[[:human genes:w:wbscr16|WBSCR16]]|0.435|
|[[:human genes:p:ptcd1|PTCD1]]|0.435|
|[[:human genes:w:wars2|WARS2]]|0.434|
|[[:human genes:t:trub2|TRUB2]]|0.43|
|[[:human genes:m:mrpl17|MRPL17]]|0.43|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.428|
|[[:human genes:n:ndufa6|NDUFA6]]|0.426|
|[[:human genes:m:mrpl22|MRPL22]]|0.423|
|[[:human genes:m:mrpl11|MRPL11]]|0.421|
|[[:human genes:m:mrps24|MRPS24]]|0.421|
|[[:human genes:h:higd2a|HIGD2A]]|0.421|
|[[:human genes:n:ndufa11|NDUFA11]]|0.42|
|[[:human genes:m:mrp63|MRP63]]|0.418|
|[[:human genes:m:mrpl20|MRPL20]]|0.416|
|[[:human genes:n:ndufa8|NDUFA8]]|0.416|
|[[:human genes:c:cox20|COX20]]|0.415|
|[[:human genes:m:mrpl2|MRPL2]]|0.415|
|[[:human genes:m:mrps22|MRPS22]]|0.414|
|[[:human genes:n:ndufb9|NDUFB9]]|0.413|
|[[:human genes:f:fastkd5|FASTKD5]]|0.41|
|[[:human genes:n:ndufs7|NDUFS7]]|0.41|
|[[:human genes:n:ndufs8|NDUFS8]]|0.409|
|[[:human genes:i:iba57|IBA57]]|0.407|
|[[:human genes:c:coq2|COQ2]]|0.405|
|[[:human genes:s:slc25a3|SLC25A3]]|0.403|
|[[:human genes:m:mrps28|MRPS28]]|0.403|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.402|
|[[:human genes:m:mrpl15|MRPL15]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1220
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.83 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MALSU1 Expression in NALM6 Cells: 4.83'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>