MAOA [The Human Chemical-Genetic Interaction Map Project]

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======= MAOA =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MAOA
  * **<color #00a2e8>Official Name</color>**: monoamine oxidase A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4128|4128]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P21397|P21397]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MAOA&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MAOA|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/309850|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is one of two neighboring gene family members that encode mitochondrial enzymes which catalyze the oxidative deamination of amines, such as dopamine, norepinephrine, and serotonin. Mutation of this gene results in Brunner syndrome. This gene has also been associated with a variety of other psychiatric disorders, including antisocial behavior. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pyr redox|
|FAD binding 3|
|DAO|
|Amino oxidase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|primary amine oxidase activity|
|dopamine catabolic process|
|catecholamine catabolic process|
|catechol-containing compound catabolic process|
|phenol-containing compound catabolic process|
|neurotransmitter catabolic process|
|dopamine metabolic process|
|catecholamine metabolic process|
|catechol-containing compound metabolic process|
|cellular biogenic amine metabolic process|
|cellular amine metabolic process|
|amine metabolic process|
|organic hydroxy compound catabolic process|
|phenol-containing compound metabolic process|
|neurotransmitter metabolic process|
|drug catabolic process|
|mitochondrial outer membrane|
|ammonium ion metabolic process|
|regulation of neurotransmitter levels|
|aromatic compound catabolic process|
|organic hydroxy compound metabolic process|
|organic cyclic compound catabolic process|
|drug metabolic process|
|cytokine-mediated signaling pathway|
|oxidation-reduction process|
|cellular response to cytokine stimulus|
|organonitrogen compound catabolic process|
|response to cytokine|
|mitochondrion|
|positive regulation of signal transduction|
|organic substance catabolic process|
|cellular catabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp436|Dynasore 7μM R08 exp436]]|-2.19|
|[[:results:exp528|TGF-beta1 44ng/ml R08 exp528]]|-2.09|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|1.72|
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|1.74|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|1.93|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18513
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -5.01 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MAOA Expression in NALM6 Cells: -5.01'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>