MAOB [The Human Chemical-Genetic Interaction Map Project]

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======= MAOB =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MAOB
  * **<color #00a2e8>Official Name</color>**: monoamine oxidase B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4129|4129]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P27338|P27338]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MAOB&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MAOB|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/309860|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene belongs to the flavin monoamine oxidase family. It is a enzyme located in the mitochondrial outer membrane. It catalyzes the oxidative deamination of biogenic and xenobiotic amines and plays an important role in the metabolism of neuroactive and vasoactive amines in the central nervous sysytem and peripheral tissues. This protein preferentially degrades benzylamine and phenylethylamine. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Amino oxidase|
|FAD binding 2|
|FAD oxidored|
|DAO|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of serotonin secretion|
|response to aluminum ion|
|primary amine oxidase activity|
|positive regulation of dopamine metabolic process|
|positive regulation of catecholamine metabolic process|
|regulation of serotonin secretion|
|mitochondrial envelope|
|hydrogen peroxide biosynthetic process|
|dopamine catabolic process|
|positive regulation of cellular amine metabolic process|
|catechol-containing compound catabolic process|
|catecholamine catabolic process|
|response to selenium ion|
|phenol-containing compound catabolic process|
|antibiotic biosynthetic process|
|regulation of catecholamine metabolic process|
|regulation of dopamine metabolic process|
|response to corticosterone|
|neurotransmitter catabolic process|
|negative regulation of neurotransmitter transport|
|reactive oxygen species biosynthetic process|
|dopamine metabolic process|
|response to mineralocorticoid|
|hydrogen peroxide metabolic process|
|substantia nigra development|
|catecholamine metabolic process|
|catechol-containing compound metabolic process|
|flavin adenine dinucleotide binding|
|neural nucleus development|
|organic hydroxy compound catabolic process|
|electron transfer activity|
|regulation of cellular amine metabolic process|
|phenol-containing compound metabolic process|
|midbrain development|
|neurotransmitter metabolic process|
|antibiotic metabolic process|
|reactive oxygen species metabolic process|
|response to ethanol|
|regulation of neurotransmitter transport|
|response to glucocorticoid|
|drug catabolic process|
|negative regulation of ion transport|
|response to corticosteroid|
|mitochondrial outer membrane|
|electron transport chain|
|response to ketone|
|ammonium ion metabolic process|
|negative regulation of secretion by cell|
|cofactor biosynthetic process|
|negative regulation of secretion|
|response to alcohol|
|response to antibiotic|
|response to lipopolysaccharide|
|response to molecule of bacterial origin|
|response to steroid hormone|
|regulation of neurotransmitter levels|
|response to metal ion|
|generation of precursor metabolites and energy|
|cofactor metabolic process|
|aromatic compound catabolic process|
|organic hydroxy compound metabolic process|
|organic cyclic compound catabolic process|
|negative regulation of transport|
|drug metabolic process|
|response to toxic substance|
|response to inorganic substance|
|response to bacterium|
|regulation of ion transport|
|brain development|
|regulation of secretion by cell|
|head development|
|regulation of secretion|
|response to lipid|
|protein homodimerization activity|
|response to hormone|
|response to organic cyclic compound|
|oxidation-reduction process|
|central nervous system development|
|response to drug|
|organonitrogen compound catabolic process|
|mitochondrion|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|organic substance catabolic process|
|cellular catabolic process|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|2.3|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7491
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.03 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MAOB Expression in NALM6 Cells: 0.03'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>