MAP1S [The Human Chemical-Genetic Interaction Map Project]

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======= MAP1S =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MAP1S
  * **<color #00a2e8>Official Name</color>**: microtubule associated protein 1S
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55201|55201]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q66K74|Q66K74]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MAP1S&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MAP1S|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607573|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of chromatin disassembly|
|deoxyribonuclease activity|
|regulation of chromatin assembly or disassembly|
|mitochondrion transport along microtubule|
|establishment of mitochondrion localization, microtubule-mediated|
|establishment of mitochondrion localization|
|regulation of microtubule depolymerization|
|microtubule associated complex|
|beta-tubulin binding|
|mitochondrion localization|
|tubulin binding|
|organelle transport along microtubule|
|regulation of microtubule polymerization or depolymerization|
|regulation of protein depolymerization|
|microtubule bundle formation|
|cell projection|
|dendrite development|
|regulation of protein complex disassembly|
|spindle|
|transport along microtubule|
|cytoskeleton-dependent intracellular transport|
|microtubule-based transport|
|regulation of microtubule cytoskeleton organization|
|regulation of chromatin organization|
|actin filament binding|
|regulation of microtubule-based process|
|microtubule binding|
|autophagy|
|process utilizing autophagic mechanism|
|actin binding|
|synapse|
|microtubule-based movement|
|microtubule|
|regulation of chromosome organization|
|regulation of supramolecular fiber organization|
|establishment of organelle localization|
|neuronal cell body|
|axonogenesis|
|axon development|
|dendrite|
|cell morphogenesis involved in neuron differentiation|
|microtubule cytoskeleton organization|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|cell part morphogenesis|
|regulation of cytoskeleton organization|
|cell junction|
|cell morphogenesis involved in differentiation|
|organelle localization|
|neuron projection development|
|microtubule-based process|
|perinuclear region of cytoplasm|
|cell morphogenesis|
|brain development|
|DNA metabolic process|
|head development|
|neuron development|
|cellular component morphogenesis|
|nucleolus|
|apoptotic process|
|central nervous system development|
|neuron differentiation|
|programmed cell death|
|identical protein binding|
|cell death|
|cytoskeleton organization|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|regulation of organelle organization|
|DNA binding|
|intracellular transport|
|generation of neurons|
|movement of cell or subcellular component|
|neurogenesis|
|cell development|
|cellular catabolic process|
|establishment of localization in cell|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8005
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.34 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MAP1S Expression in NALM6 Cells: 5.34'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>