MAP4 [The Human Chemical-Genetic Interaction Map Project]

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======= MAP4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MAP4
  * **<color #00a2e8>Official Name</color>**: microtubule associated protein 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4134|4134]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P27816|P27816]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MAP4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MAP4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/157132|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a major non-neuronal microtubule-associated protein. This protein contains a domain similar to the microtubule-binding domains of neuronal microtubule-associated protein (MAP2) and microtubule-associated protein tau (MAPT/TAU). This protein promotes microtubule assembly, and has been shown to counteract destabilization of interphase microtubule catastrophe promotion. Cyclin B was found to interact with this protein, which targets cell division cycle 2 (CDC2) kinase to microtubules. The phosphorylation of this protein affects microtubule properties and cell cycle progression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Non-neuronal microtubule-associated protein. Promotes microtubule assembly. {ECO:0000269|PubMed:10791892}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Tubulin-binding|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|microtubule sliding|
|negative regulation of non-motile cilium assembly|
|negative regulation of cilium assembly|
|regulation of non-motile cilium assembly|
|negative regulation of plasma membrane bounded cell projection assembly|
|microtubule associated complex|
|establishment of spindle orientation|
|negative regulation of organelle assembly|
|establishment of spindle localization|
|spindle localization|
|mitotic spindle organization|
|mitotic spindle|
|regulation of cilium assembly|
|microtubule cytoskeleton organization involved in mitosis|
|axoneme|
|establishment of cell polarity|
|microtubule cytoskeleton|
|spindle organization|
|negative regulation of cell projection organization|
|structural molecule activity|
|establishment or maintenance of cell polarity|
|regulation of plasma membrane bounded cell projection assembly|
|regulation of cell projection assembly|
|regulation of organelle assembly|
|microtubule binding|
|postsynaptic density|
|microtubule-based movement|
|axon|
|microtubule|
|neuron projection|
|establishment of organelle localization|
|negative regulation of organelle organization|
|microtubule cytoskeleton organization|
|cell division|
|organelle localization|
|mitotic cell cycle process|
|neuron projection development|
|microtubule-based process|
|mitotic cell cycle|
|regulation of plasma membrane bounded cell projection organization|
|negative regulation of cellular component organization|
|regulation of cell projection organization|
|neuron development|
|regulation of cellular component biogenesis|
|cell cycle process|
|neuron differentiation|
|cytoskeleton organization|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|regulation of organelle organization|
|cell cycle|
|RNA binding|
|generation of neurons|
|movement of cell or subcellular component|
|neurogenesis|
|cell development|
|establishment of localization in cell|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|-2.48|
|[[:results:exp107|UMK57 0.6μM R03 exp107]]|-1.86|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18267
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.49 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MAP4 Expression in NALM6 Cells: 7.49'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>