MAP6 [The Human Chemical-Genetic Interaction Map Project]

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======= MAP6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MAP6
  * **<color #00a2e8>Official Name</color>**: microtubule associated protein 6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4135|4135]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96JE9|Q96JE9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MAP6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MAP6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601783|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a microtubule-associated protein. The encoded protein is a calmodulin-binding and calmodulin-regulated protein that is involved in microtubule stabilization. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in microtubule stabilization in many cell types, including neuronal cells (By similarity). Specifically has microtubule cold stabilizing activity (By similarity). Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking via its interaction with TMEM106B (PubMed:24357581). Regulates KIF5A-mediated axonal cargo transport (By similarity). Regulates axonal growth during neuron polarization (By similarity). {ECO:0000250|UniProtKB:Q63560, ECO:0000269|PubMed:24357581}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|STOP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Golgi-associated vesicle|
|transport vesicle membrane|
|lysosome localization|
|dendrite morphogenesis|
|cis-Golgi network|
|positive regulation of axonogenesis|
|dendrite development|
|positive regulation of cell morphogenesis involved in differentiation|
|cytoskeleton-dependent intracellular transport|
|regulation of axonogenesis|
|regulation of microtubule cytoskeleton organization|
|calmodulin binding|
|regulation of microtubule-based process|
|microtubule binding|
|positive regulation of neuron projection development|
|axon|
|regulation of cell morphogenesis involved in differentiation|
|microtubule|
|positive regulation of neuron differentiation|
|positive regulation of cell projection organization|
|dendrite|
|cell morphogenesis involved in neuron differentiation|
|positive regulation of neurogenesis|
|microtubule cytoskeleton organization|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|regulation of cell morphogenesis|
|cell projection morphogenesis|
|regulation of neuron projection development|
|cell part morphogenesis|
|positive regulation of nervous system development|
|regulation of cytoskeleton organization|
|positive regulation of cell development|
|cell morphogenesis involved in differentiation|
|organelle localization|
|regulation of neuron differentiation|
|neuron projection development|
|microtubule-based process|
|regulation of plasma membrane bounded cell projection organization|
|perinuclear region of cytoplasm|
|regulation of cell projection organization|
|cell morphogenesis|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|regulation of nervous system development|
|regulation of cell development|
|positive regulation of cell differentiation|
|neuron differentiation|
|regulation of anatomical structure morphogenesis|
|cytoskeleton organization|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|positive regulation of developmental process|
|intracellular transport|
|generation of neurons|
|neurogenesis|
|cell development|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|establishment of localization in cell|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|-2.32|
|[[:results:exp289|Hydroxyurea 15μM R06 exp289]]|-2.05|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|1.71|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|1.74|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|1.8|
|[[:results:exp534|Trientine 500μM R08 exp534]]|2.14|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17421
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.88 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MAP6 Expression in NALM6 Cells: -0.88'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>