MAPK13 [The Human Chemical-Genetic Interaction Map Project]

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======= MAPK13 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MAPK13
  * **<color #00a2e8>Official Name</color>**: mitogen-activated protein kinase 13
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5603|5603]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O15264|O15264]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MAPK13&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MAPK13|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602899|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK13 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK13 is one of the less studied p38 MAPK isoforms. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in the regulation of protein translation by phosphorylating and inactivating EEF2K. Involved in cytoskeletal remodeling through phosphorylation of MAPT and STMN1. Mediates UV irradiation induced up-regulation of the gene expression of CXCL14. Plays an important role in the regulation of epidermal keratinocyte differentiation, apoptosis and skin tumor development. Phosphorylates the transcriptional activator MYB in response to stress which leads to rapid MYB degradation via a proteasome-dependent pathway. MAPK13 also phosphorylates and down-regulates PRKD1 during regulation of insulin secretion in pancreatic beta cells. {ECO:0000269|PubMed:11500363, ECO:0000269|PubMed:11943212, ECO:0000269|PubMed:15632108, ECO:0000269|PubMed:17256148, ECO:0000269|PubMed:18006338, ECO:0000269|PubMed:18367666, ECO:0000269|PubMed:20478268, ECO:0000269|PubMed:9731215}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase Tyr|
|Pkinase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cellular response to anisomycin|
|response to anisomycin|
|cellular response to sorbitol|
|response to sorbitol|
|cellular response to sodium arsenite|
|response to sodium arsenite|
|cellular response to salt|
|response to herbicide|
|MAP kinase activity|
|response to insecticide|
|response to salt|
|cellular response to arsenic-containing substance|
|response to arsenic-containing substance|
|cellular response to hydrogen peroxide|
|response to osmotic stress|
|cellular response to carbohydrate stimulus|
|cellular response to UV|
|positive regulation of interleukin-6 production|
|response to antineoplastic agent|
|stress-activated MAPK cascade|
|cellular response to light stimulus|
|cellular response to antibiotic|
|response to hydrogen peroxide|
|cellular response to reactive oxygen species|
|positive regulation of inflammatory response|
|regulation of interleukin-6 production|
|stress-activated protein kinase signaling cascade|
|response to UV|
|response to carbohydrate|
|peptidyl-serine phosphorylation|
|cellular response to radiation|
|cellular response to interleukin-1|
|response to reactive oxygen species|
|peptidyl-serine modification|
|response to interleukin-1|
|cellular response to toxic substance|
|cellular response to oxidative stress|
|response to antibiotic|
|response to light stimulus|
|cellular response to environmental stimulus|
|cellular response to abiotic stimulus|
|regulation of inflammatory response|
|protein serine/threonine kinase activity|
|MAPK cascade|
|response to oxidative stress|
|signal transduction by protein phosphorylation|
|cellular response to drug|
|response to radiation|
|positive regulation of cytokine production|
|positive regulation of defense response|
|response to toxic substance|
|response to inorganic substance|
|cellular response to organonitrogen compound|
|positive regulation of response to external stimulus|
|cellular response to nitrogen compound|
|regulation of cytokine production|
|regulation of defense response|
|peptidyl-amino acid modification|
|protein phosphorylation|
|response to organonitrogen compound|
|cellular response to cytokine stimulus|
|response to drug|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|regulation of response to external stimulus|
|response to cytokine|
|response to abiotic stimulus|
|cellular response to endogenous stimulus|
|phosphorylation|
|cell cycle|
|response to endogenous stimulus|
|regulation of response to stress|
|ATP binding|
|response to oxygen-containing compound|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of multicellular organismal process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp20|Etoposide 10μM R00 exp20]]|-2.44|
|[[:results:exp298|Sucrose 20000μM R06 exp298]]|-1.86|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-1.75|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|1.76|
|[[:results:exp10|CCCP 0.1μM R00 exp10]]|1.85|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|2|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3176
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.15 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MAPK13 Expression in NALM6 Cells: 6.15'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>