MAPK8IP2 [The Human Chemical-Genetic Interaction Map Project]

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======= MAPK8IP2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MAPK8IP2
  * **<color #00a2e8>Official Name</color>**: mitogen-activated protein kinase 8 interacting protein 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23542|23542]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13387|Q13387]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MAPK8IP2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MAPK8IP2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607755|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a scaffold protein that is thought to be involved in the regulation of the c-Jun amino-terminal kinase signaling pathway. This protein has been shown to interact with and regulate the activity of MAPK8/JNK1 and MAP2K7/MKK7 kinases. [provided by RefSeq, Jun 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**:  The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. JIP2 inhibits IL1 beta-induced apoptosis in insulin-secreting cells. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity). {ECO:0000250}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|nonassociative learning|
|MAP-kinase scaffold activity|
|signal complex assembly|
|mating behavior|
|regulation of AMPA receptor activity|
|reproductive behavior|
|behavioral fear response|
|behavioral defense response|
|mating|
|fear response|
|regulation of NMDA receptor activity|
|kinesin binding|
|social behavior|
|intraspecies interaction between organisms|
|dendrite morphogenesis|
|excitatory postsynaptic potential|
|regulation of glutamate receptor signaling pathway|
|chemical synaptic transmission, postsynaptic|
|multi-organism behavior|
|multicellular organismal response to stress|
|regulation of synaptic transmission, glutamatergic|
|regulation of neurotransmitter receptor activity|
|amyloid-beta binding|
|JNK cascade|
|regulation of postsynaptic membrane potential|
|dendrite development|
|stress-activated MAPK cascade|
|stress-activated protein kinase signaling cascade|
|learning|
|positive regulation of stress-activated MAPK cascade|
|positive regulation of stress-activated protein kinase signaling cascade|
|regulation of cation channel activity|
|regulation of signaling receptor activity|
|regulation of JNK cascade|
|structural molecule activity|
|negative regulation of apoptotic signaling pathway|
|regulation of stress-activated MAPK cascade|
|regulation of stress-activated protein kinase signaling cascade|
|postsynaptic density|
|regulation of ion transmembrane transporter activity|
|learning or memory|
|regulation of transmembrane transporter activity|
|protein-containing complex binding|
|regulation of transporter activity|
|cognition|
|regulation of cation transmembrane transport|
|MAPK cascade|
|neuronal cell body|
|signal transduction by protein phosphorylation|
|regulation of apoptotic signaling pathway|
|chemical synaptic transmission|
|anterograde trans-synaptic signaling|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|regulation of membrane potential|
|cell morphogenesis involved in neuron differentiation|
|trans-synaptic signaling|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|synaptic signaling|
|protein kinase binding|
|regulation of ion transmembrane transport|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|cell part morphogenesis|
|positive regulation of MAPK cascade|
|cell morphogenesis involved in differentiation|
|regulation of transmembrane transport|
|behavior|
|protein-containing complex|
|neuron projection development|
|regulation of ion transport|
|cell morphogenesis|
|regulation of cellular response to stress|
|regulation of MAPK cascade|
|neuron development|
|cellular component morphogenesis|
|multicellular organismal reproductive process|
|sexual reproduction|
|cellular protein-containing complex assembly|
|multicellular organism reproduction|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|protein phosphorylation|
|multi-organism reproductive process|
|negative regulation of cell death|
|neuron differentiation|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|positive regulation of phosphorylation|
|cell-cell signaling|
|plasma membrane bounded cell projection organization|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|cell projection organization|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|phosphorylation|
|defense response|
|negative regulation of cell communication|
|negative regulation of signaling|
|nervous system process|
|reproductive process|
|reproduction|
|regulation of protein phosphorylation|
|regulation of response to stress|
|generation of neurons|
|regulation of apoptotic process|
|protein-containing complex assembly|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|neurogenesis|
|cell development|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|regulation of transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp114|A-196 10μM R03 exp114]]|-1.9|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.493|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3040
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.8 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MAPK8IP2 Expression in NALM6 Cells: 1.8'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>