MAPKAPK5 [The Human Chemical-Genetic Interaction Map Project]

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======= MAPKAPK5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MAPKAPK5
  * **<color #00a2e8>Official Name</color>**: MAPK activated protein kinase 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8550|8550]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8IW41|Q8IW41]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MAPKAPK5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MAPKAPK5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606723|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Tumor suppressor serine/threonine-protein kinase involved in mTORC1 signaling and post-transcriptional regulation. Phosphorylates FOXO3, ERK3/MAPK6, ERK4/MAPK4, HSP27/HSPB1, p53/TP53 and RHEB. Acts as a tumor suppressor by mediating Ras- induced senescence and phosphorylating p53/TP53. Involved in post- transcriptional regulation of MYC by mediating phosphorylation of FOXO3: phosphorylation of FOXO3 leads to promote nuclear localization of FOXO3, enabling expression of miR-34b and miR-34c, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent MYC translation. Acts as a negative regulator of mTORC1 signaling by mediating phosphorylation and inhibition of RHEB. Part of the atypical MAPK signaling via its interaction with ERK3/MAPK6 or ERK4/MAPK4: the precise role of the complex formed with ERK3/MAPK6 or ERK4/MAPK4 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPK (ERK3/MAPK6 or ERK4/MAPK4), ERK3/MAPK6 (or ERK4/MAPK4) is phosphorylated and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6 (or ERK4/MAPK4). Mediates phosphorylation of HSP27/HSPB1 in response to PKA/PRKACA stimulation, inducing F-actin rearrangement. {ECO:0000269|PubMed:17254968, ECO:0000269|PubMed:17728103, ECO:0000269|PubMed:19166925, ECO:0000269|PubMed:21329882, ECO:0000269|PubMed:9628874}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase Tyr|
|Pkinase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|calcium-dependent protein serine/threonine kinase activity|
|stress-induced premature senescence|
|positive regulation of telomere capping|
|MAP kinase kinase activity|
|mitogen-activated protein kinase binding|
|calmodulin-dependent protein kinase activity|
|regulation of telomere capping|
|cellular senescence|
|positive regulation of telomere maintenance via telomerase|
|positive regulation of telomerase activity|
|positive regulation of telomere maintenance via telomere lengthening|
|negative regulation of TOR signaling|
|positive regulation of telomere maintenance|
|regulation of telomerase activity|
|regulation of telomere maintenance via telomerase|
|regulation of telomere maintenance via telomere lengthening|
|cell aging|
|p53 binding|
|positive regulation of DNA biosynthetic process|
|regulation of telomere maintenance|
|regulation of TOR signaling|
|regulation of DNA biosynthetic process|
|activation of MAPK activity|
|peptidyl-serine phosphorylation|
|positive regulation of chromosome organization|
|regulation of signal transduction by p53 class mediator|
|protein autophosphorylation|
|positive regulation of DNA metabolic process|
|peptidyl-serine modification|
|calmodulin binding|
|Ras protein signal transduction|
|positive regulation of MAP kinase activity|
|aging|
|small GTPase mediated signal transduction|
|activation of protein kinase activity|
|positive regulation of protein serine/threonine kinase activity|
|regulation of MAP kinase activity|
|regulation of chromosome organization|
|regulation of translation|
|regulation of DNA metabolic process|
|protein serine/threonine kinase activity|
|MAPK cascade|
|signal transduction by protein phosphorylation|
|regulation of cellular amide metabolic process|
|negative regulation of intracellular signal transduction|
|regulation of protein serine/threonine kinase activity|
|posttranscriptional regulation of gene expression|
|positive regulation of protein kinase activity|
|positive regulation of MAPK cascade|
|positive regulation of kinase activity|
|positive regulation of organelle organization|
|positive regulation of transferase activity|
|regulation of MAPK cascade|
|regulation of protein kinase activity|
|regulation of kinase activity|
|peptidyl-amino acid modification|
|protein phosphorylation|
|regulation of transferase activity|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|positive regulation of phosphorylation|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of cellular component organization|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|phosphorylation|
|regulation of organelle organization|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|ATP binding|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|positive regulation of signal transduction|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|-2.25|
|[[:results:exp146|Quinacrine 2.5μM R03 exp146]]|-2.07|
|[[:results:exp125|GSK461364A 0.005μM R03 exp125]]|-2|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|-1.86|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|-1.79|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|1.7|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|1.7|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|1.75|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|1.78|
|[[:results:exp360|Genistein 15μM R07 exp360]]|1.82|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|1.82|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|1.88|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|1.91|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|2.01|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|2.03|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|2.26|
|[[:results:exp223|Cabazitaxel 0.001μM R05 exp223]]|2.3|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|2.39|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|2.56|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|2.57|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|2.96|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|3.19|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:ahcyl1|AHCYL1]]|0.723|
|[[:human genes:s:slc4a7|SLC4A7]]|0.618|
|[[:human genes:m:mapk6|MAPK6]]|0.574|
|[[:human genes:m:mgat1|MGAT1]]|0.44|
|[[:human genes:v:vps35|VPS35]]|0.419|
|[[:human genes:a:ahcyl2|AHCYL2]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6159
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.26 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MAPKAPK5 Expression in NALM6 Cells: 7.26'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>