MAPRE3 [The Human Chemical-Genetic Interaction Map Project]

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======= MAPRE3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MAPRE3
  * **<color #00a2e8>Official Name</color>**: microtubule associated protein RP/EB family member 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=22924|22924]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UPY8|Q9UPY8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MAPRE3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MAPRE3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605788|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plus-end tracking protein (+TIP) that binds to the plus- end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:28814570). Promotes elongation of CAMSAP2-decorated microtubule stretches on the minus-end of microtubules (PubMed:28814570). May play a role in cell migration (By similarity). {ECO:0000250, ECO:0000269|PubMed:19255245, ECO:0000269|PubMed:28814570}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|EB1|
|CH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of microtubule plus-end binding|
|positive regulation of microtubule plus-end binding|
|mitotic spindle astral microtubule end|
|protein localization to microtubule end|
|protein localization to microtubule plus-end|
|positive regulation of microtubule binding|
|regulation of microtubule binding|
|protein localization to microtubule|
|microtubule plus-end binding|
|microtubule plus-end|
|spindle midzone|
|positive regulation of cyclin-dependent protein serine/threonine kinase activity|
|protein localization to microtubule cytoskeleton|
|positive regulation of cyclin-dependent protein kinase activity|
|protein localization to cytoskeleton|
|regulation of microtubule polymerization|
|cytoplasmic microtubule|
|regulation of microtubule polymerization or depolymerization|
|positive regulation of protein binding|
|regulation of cyclin-dependent protein serine/threonine kinase activity|
|spindle assembly|
|regulation of cyclin-dependent protein kinase activity|
|spindle organization|
|microtubule organizing center|
|midbody|
|positive regulation of binding|
|protein C-terminus binding|
|regulation of microtubule cytoskeleton organization|
|regulation of protein binding|
|regulation of microtubule-based process|
|regulation of protein polymerization|
|microtubule binding|
|microtubule|
|positive regulation of protein serine/threonine kinase activity|
|regulation of supramolecular fiber organization|
|regulation of binding|
|positive regulation of cell cycle|
|regulation of protein complex assembly|
|protein kinase binding|
|microtubule cytoskeleton organization|
|cell division|
|regulation of protein serine/threonine kinase activity|
|positive regulation of protein kinase activity|
|regulation of cytoskeleton organization|
|positive regulation of kinase activity|
|positive regulation of transferase activity|
|microtubule-based process|
|protein localization to organelle|
|organelle assembly|
|regulation of protein kinase activity|
|regulation of kinase activity|
|regulation of cellular component biogenesis|
|regulation of transferase activity|
|cell cycle process|
|positive regulation of protein phosphorylation|
|positive regulation of phosphorylation|
|identical protein binding|
|cytoskeleton organization|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|regulation of cell cycle|
|positive regulation of protein modification process|
|regulation of organelle organization|
|cell cycle|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|positive regulation of transcription, DNA-templated|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of protein metabolic process|
|positive regulation of RNA metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp490|Hydroxychloroquine 30μM R08 exp490]]|-1.99|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|-1.77|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15973
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.03 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MAPRE3 Expression in NALM6 Cells: 0.03'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>