MARK2 [The Human Chemical-Genetic Interaction Map Project]

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======= MARK2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MARK2
  * **<color #00a2e8>Official Name</color>**: microtubule affinity regulating kinase 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2011|2011]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q7KZI7|Q7KZI7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MARK2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MARK2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600526|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the Par-1 family of serine/threonine protein kinases. The protein is an important regulator of cell polarity in epithelial and neuronal cells, and also controls the stability of microtubules through phosphorylation and inactivation of several microtubule-associating proteins. The protein localizes to cell membranes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Serine/threonine-protein kinase involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4, MAPT/TAU, and RAB11FIP2. Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule- dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells. {ECO:0000269|PubMed:11433294, ECO:0000269|PubMed:12429843, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15158914, ECO:0000269|PubMed:15324659, ECO:0000269|PubMed:15365179, ECO:0000269|PubMed:16775013, ECO:0000269|PubMed:16980613, ECO:0000269|PubMed:18626018, ECO:0000269|PubMed:20194617}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase Tyr|
|Pkinase|
|KA1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|establishment or maintenance of cell polarity regulating cell shape|
|microtubule bundle|
|regulation of microtubule binding|
|tau-protein kinase activity|
|protein kinase activator activity|
|autophagy of mitochondrion|
|mitochondrion disassembly|
|tau protein binding|
|establishment or maintenance of epithelial cell apical/basal polarity|
|mitochondrion localization|
|establishment or maintenance of apical/basal cell polarity|
|establishment or maintenance of bipolar cell polarity|
|lateral plasma membrane|
|organelle disassembly|
|actin filament|
|peptidyl-threonine phosphorylation|
|peptidyl-threonine modification|
|establishment of cell polarity|
|neuron migration|
|regulation of cell shape|
|lipid binding|
|peptidyl-serine phosphorylation|
|regulation of axonogenesis|
|regulation of microtubule cytoskeleton organization|
|protein autophosphorylation|
|establishment or maintenance of cell polarity|
|peptidyl-serine modification|
|magnesium ion binding|
|regulation of protein binding|
|regulation of microtubule-based process|
|autophagy|
|process utilizing autophagic mechanism|
|positive regulation of neuron projection development|
|regulation of cell morphogenesis involved in differentiation|
|cadherin binding|
|activation of protein kinase activity|
|Wnt signaling pathway|
|cell-cell signaling by wnt|
|protein serine/threonine kinase activity|
|positive regulation of neuron differentiation|
|regulation of binding|
|positive regulation of cell projection organization|
|cellular component disassembly|
|axon development|
|dendrite|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|mitochondrion organization|
|positive regulation of neurogenesis|
|microtubule cytoskeleton organization|
|regulation of cell morphogenesis|
|regulation of neuron projection development|
|positive regulation of protein kinase activity|
|positive regulation of nervous system development|
|regulation of cytoskeleton organization|
|positive regulation of cell development|
|positive regulation of kinase activity|
|organelle localization|
|regulation of neuron differentiation|
|positive regulation of transferase activity|
|neuron projection development|
|microtubule-based process|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|regulation of protein kinase activity|
|neuron development|
|regulation of neurogenesis|
|regulation of kinase activity|
|peptidyl-amino acid modification|
|regulation of nervous system development|
|regulation of cell development|
|cell migration|
|positive regulation of cell differentiation|
|protein phosphorylation|
|regulation of transferase activity|
|neuron differentiation|
|positive regulation of protein phosphorylation|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|localization of cell|
|cell motility|
|cytoskeleton organization|
|cell-cell signaling|
|plasma membrane bounded cell projection organization|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|cell projection organization|
|positive regulation of cellular component organization|
|positive regulation of protein modification process|
|mitochondrion|
|phosphorylation|
|regulation of organelle organization|
|locomotion|
|positive regulation of developmental process|
|RNA binding|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|ATP binding|
|generation of neurons|
|movement of cell or subcellular component|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|neurogenesis|
|cell development|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|cellular catabolic process|
|regulation of cell differentiation|
|regulation of protein modification process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|-3.52|
|[[:results:exp261|ABT-702 5μM R06 exp261]]|-2.68|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|-2.19|
|[[:results:exp432|YM155 0.001μM R08 exp432]]|-2.1|
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|-2.07|
|[[:results:exp249|Vinorelbine 0.001μM R05 exp249]]|-1.95|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|-1.93|
|[[:results:exp209|Deguelin 0.15μM R05 exp209]]|-1.77|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|1.88|
|[[:results:exp372|Ibrutinib 1μM R07 exp372]]|1.88|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|1.89|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|2.09|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 4/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|1/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13791
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.89 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MARK2 Expression in NALM6 Cells: 5.89'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>