MARS [The Human Chemical-Genetic Interaction Map Project]

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======= MARS =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MARS1
  * **<color #00a2e8>Official Name</color>**: methionyl-tRNA synthetase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4141|4141]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P56192|P56192]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MARS&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MARS|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/156560|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. {ECO:0000269|PubMed:11714285}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|WHEP-TRS|
|tRNA-synt 1g|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|methionyl-tRNA aminoacylation|
|methionine-tRNA ligase activity|
|positive regulation of transcription of nucleolar large rRNA by RNA polymerase I|
|aminoacyl-tRNA synthetase multienzyme complex|
|regulation of transcription of nucleolar large rRNA by RNA polymerase I|
|cellular response to platelet-derived growth factor stimulus|
|response to platelet-derived growth factor|
|rRNA transcription|
|positive regulation of transcription by RNA polymerase I|
|regulation of transcription by RNA polymerase I|
|cellular response to epidermal growth factor stimulus|
|tRNA aminoacylation for protein translation|
|response to epidermal growth factor|
|tRNA aminoacylation|
|amino acid activation|
|tRNA binding|
|ncRNA transcription|
|cellular response to starvation|
|cellular response to insulin stimulus|
|tRNA metabolic process|
|response to starvation|
|response to insulin|
|cellular response to nutrient levels|
|cellular response to extracellular stimulus|
|cellular response to peptide hormone stimulus|
|cellular amino acid metabolic process|
|cellular response to peptide|
|cellular response to external stimulus|
|translation|
|response to peptide hormone|
|peptide biosynthetic process|
|response to peptide|
|ncRNA metabolic process|
|response to nutrient levels|
|cellular response to growth factor stimulus|
|amide biosynthetic process|
|peptide metabolic process|
|response to extracellular stimulus|
|response to growth factor|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|cellular response to nitrogen compound|
|cellular amide metabolic process|
|nucleolus|
|carboxylic acid metabolic process|
|response to hormone|
|response to organonitrogen compound|
|oxoacid metabolic process|
|organic acid metabolic process|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|cellular response to endogenous stimulus|
|organic cyclic compound biosynthetic process|
|organonitrogen compound biosynthetic process|
|response to endogenous stimulus|
|ATP binding|
|positive regulation of transcription, DNA-templated|
|response to oxygen-containing compound|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|RNA metabolic process|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|positive regulation of RNA metabolic process|
|small molecule metabolic process|
|macromolecule biosynthetic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|membrane|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp235|Geldanamycin 0.01μM R05 exp235]]|-2.23|
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|-2.04|
|[[:results:exp236|GSK2606414 1μM R05 exp236]]|-1.86|
|[[:results:exp58|UM131593 0.1μM R01 exp58]]|-1.86|
|[[:results:exp362|GSK-J4 1μM R07 exp362]]|-1.85|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|-1.8|
|[[:results:exp70|INK128 0.2μM R02 exp70]]|-1.79|
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|-1.71|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|1.7|
|[[:results:exp401|SNS-032 25μM R07 exp401]]|1.79|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|1.82|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|1.86|
|[[:results:exp150|SGC0649 7μM R03 exp150]]|1.93|
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|1.96|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|2.03|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|2.67|
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|2.76|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hars|HARS]]|0.691|
|[[:human genes:y:yars|YARS]]|0.585|
|[[:human genes:g:gmppb|GMPPB]]|0.58|
|[[:human genes:h:hspd1|HSPD1]]|0.571|
|[[:human genes:s:srp72|SRP72]]|0.564|
|[[:human genes:r:rnmt|RNMT]]|0.563|
|[[:human genes:c:cars|CARS]]|0.557|
|[[:human genes:n:nars|NARS]]|0.557|
|[[:human genes:g:gfpt1|GFPT1]]|0.531|
|[[:human genes:e:eprs|EPRS]]|0.529|
|[[:human genes:c:cct7|CCT7]]|0.529|
|[[:human genes:t:tti2|TTI2]]|0.521|
|[[:human genes:n:nsmce1|NSMCE1]]|0.515|
|[[:human genes:r:rbm14|RBM14]]|0.506|
|[[:human genes:r:rptor|RPTOR]]|0.503|
|[[:human genes:t:tbca|TBCA]]|0.502|
|[[:human genes:c:cep350|CEP350]]|0.499|
|[[:human genes:p:pmm2|PMM2]]|0.499|
|[[:human genes:a:aars|AARS]]|0.49|
|[[:human genes:c:csnk2b|CSNK2B]]|0.489|
|[[:human genes:m:mtor|MTOR]]|0.48|
|[[:human genes:s:srp19|SRP19]]|0.48|
|[[:human genes:r:rtcb|RTCB]]|0.477|
|[[:human genes:t:tbp|TBP]]|0.477|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.475|
|[[:human genes:p:polr3b|POLR3B]]|0.474|
|[[:human genes:p:pmpcb|PMPCB]]|0.473|
|[[:human genes:t:tbcd|TBCD]]|0.473|
|[[:human genes:s:slc35b1|SLC35B1]]|0.47|
|[[:human genes:s:seh1l|SEH1L]]|0.468|
|[[:human genes:p:pelo|PELO]]|0.467|
|[[:human genes:t:tgs1|TGS1]]|0.465|
|[[:human genes:g:gnb1l|GNB1L]]|0.465|
|[[:human genes:e:eno1|ENO1]]|0.463|
|[[:human genes:u:uap1|UAP1]]|0.46|
|[[:human genes:s:spcs2|SPCS2]]|0.459|
|[[:human genes:s:spcs3|SPCS3]]|0.458|
|[[:human genes:e:eif4e|EIF4E]]|0.458|
|[[:human genes:v:vrk1|VRK1]]|0.455|
|[[:human genes:m:meaf6|MEAF6]]|0.452|
|[[:human genes:a:alg13|ALG13]]|0.45|
|[[:human genes:i:iars|IARS]]|0.448|
|[[:human genes:z:znhit1|ZNHIT1]]|0.446|
|[[:human genes:t:telo2|TELO2]]|0.445|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.445|
|[[:human genes:s:srpr|SRPR]]|0.443|
|[[:human genes:a:alg5|ALG5]]|0.441|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.44|
|[[:human genes:e:eny2|ENY2]]|0.438|
|[[:human genes:d:dpagt1|DPAGT1]]|0.437|
|[[:human genes:o:oraov1|ORAOV1]]|0.436|
|[[:human genes:d:ddost|DDOST]]|0.433|
|[[:human genes:s:snf8|SNF8]]|0.433|
|[[:human genes:h:hmgb2|HMGB2]]|0.432|
|[[:human genes:g:gtf3a|GTF3A]]|0.431|
|[[:human genes:k:kars|KARS]]|0.43|
|[[:human genes:s:srp68|SRP68]]|0.427|
|[[:human genes:z:znf608|ZNF608]]|0.427|
|[[:human genes:p:psmg4|PSMG4]]|0.427|
|[[:human genes:p:polr3h|POLR3H]]|0.427|
|[[:human genes:h:haus8|HAUS8]]|0.426|
|[[:human genes:z:znf259|ZNF259]]|0.426|
|[[:human genes:o:oip5|OIP5]]|0.426|
|[[:human genes:g:gemin5|GEMIN5]]|0.423|
|[[:human genes:u:uba3|UBA3]]|0.423|
|[[:human genes:t:thoc3|THOC3]]|0.423|
|[[:human genes:a:abcf1|ABCF1]]|0.422|
|[[:human genes:a:alg14|ALG14]]|0.42|
|[[:human genes:p:pam16|PAM16]]|0.419|
|[[:human genes:o:otud5|OTUD5]]|0.419|
|[[:human genes:t:triap1|TRIAP1]]|0.415|
|[[:human genes:w:wdr24|WDR24]]|0.414|
|[[:human genes:d:dad1|DAD1]]|0.414|
|[[:human genes:p:pisd|PISD]]|0.413|
|[[:human genes:g:gemin8|GEMIN8]]|0.411|
|[[:human genes:t:thg1l|THG1L]]|0.41|
|[[:human genes:d:ddx20|DDX20]]|0.41|
|[[:human genes:c:crcp|CRCP]]|0.41|
|[[:human genes:m:mad2l1|MAD2L1]]|0.409|
|[[:human genes:g:gpn2|GPN2]]|0.409|
|[[:human genes:d:dpf2|DPF2]]|0.406|
|[[:human genes:d:ddx55|DDX55]]|0.406|
|[[:human genes:a:alg1|ALG1]]|0.403|
|[[:human genes:u:utp23|UTP23]]|0.403|
|[[:human genes:c:cct5|CCT5]]|0.403|
|[[:human genes:w:wars|WARS]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 708/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|27/28|
|bone|25/26|
|breast|31/33|
|central nervous system|53/56|
|cervix|4/4|
|colorectal|16/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|17/21|
|liver|20/20|
|lung|73/75|
|lymphocyte|16/16|
|ovary|25/26|
|pancreas|23/24|
|peripheral nervous system|16/16|
|plasma cell|14/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|20/22|
|urinary tract|25/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.95 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MARS Expression in NALM6 Cells: 7.95'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>