MAX [The Human Chemical-Genetic Interaction Map Project]

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======= MAX =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MAX
  * **<color #00a2e8>Official Name</color>**: MYC associated factor X
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4149|4149]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P61244|P61244]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MAX&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MAX|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/154950|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the basic helix-loop-helix leucine zipper (bHLHZ) family of transcription factors. It is able to form homodimers and heterodimers with other family members, which include Mad, Mxi1 and Myc. Myc is an oncoprotein implicated in cell proliferation, differentiation and apoptosis. The homodimers and heterodimers compete for a common DNA target site (the E box) and rearrangement among these dimer forms provides a complex system of transcriptional regulation. Mutations of this gene have been reported to be associated with hereditary pheochromocytoma. A pseudogene of this gene is located on the long arm of chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]. COMPLETENESS: complete on the 3' end. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|HLH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|MLL1 complex|
|negative regulation of G0 to G1 transition|
|regulation of G0 to G1 transition|
|protein-DNA complex|
|neuron apoptotic process|
|response to axon injury|
|E-box binding|
|neuron death|
|RNA polymerase II transcription factor complex|
|transcription coregulator activity|
|PML body|
|G1/S transition of mitotic cell cycle|
|cell cycle G1/S phase transition|
|retina development in camera-type eye|
|cellular response to starvation|
|response to starvation|
|response to insulin|
|cellular response to nutrient levels|
|nuclear chromatin|
|DNA-binding transcription repressor activity, RNA polymerase II-specific|
|cellular response to extracellular stimulus|
|cellular response to peptide hormone stimulus|
|protein-containing complex binding|
|mitotic cell cycle phase transition|
|cell cycle phase transition|
|transcription coactivator activity|
|RNA polymerase II regulatory region sequence-specific DNA binding|
|camera-type eye development|
|negative regulation of cell cycle process|
|cellular response to peptide|
|cellular response to external stimulus|
|eye development|
|visual system development|
|sensory system development|
|response to peptide hormone|
|dendrite|
|response to peptide|
|transcription by RNA polymerase II|
|protein heterodimerization activity|
|response to nutrient levels|
|response to extracellular stimulus|
|sensory organ development|
|response to wounding|
|negative regulation of cell cycle|
|mitotic cell cycle process|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|cellular response to nitrogen compound|
|DNA-binding transcription factor activity|
|mitotic cell cycle|
|regulation of cell cycle process|
|negative regulation of transcription by RNA polymerase II|
|protein homodimerization activity|
|response to hormone|
|apoptotic process|
|cell cycle process|
|response to organonitrogen compound|
|programmed cell death|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|cell death|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|organic cyclic compound biosynthetic process|
|negative regulation of RNA metabolic process|
|cell cycle|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|RNA metabolic process|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp162|BI-D1870 2μM R04 exp162]]|1.73|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|1.8|
|[[:results:exp17|DABN 20μM R00 exp17]]|1.83|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|1.9|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|1.94|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|2.14|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|2.25|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|3.98|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:u:ube3a|UBE3A]]|0.508|
|[[:human genes:m:mllt1|MLLT1]]|0.506|
|[[:human genes:c:ccdc101|CCDC101]]|0.481|
|[[:human genes:m:meaf6|MEAF6]]|0.476|
|[[:human genes:d:dcaf7|DCAF7]]|0.473|
|[[:human genes:s:smarcd1|SMARCD1]]|0.466|
|[[:human genes:m:med23|MED23]]|0.462|
|[[:human genes:m:med16|MED16]]|0.456|
|[[:human genes:d:dad1|DAD1]]|0.452|
|[[:human genes:w:wdr24|WDR24]]|0.449|
|[[:human genes:f:fbxo11|FBXO11]]|0.446|
|[[:human genes:t:thoc6|THOC6]]|0.437|
|[[:human genes:r:rnmt|RNMT]]|0.433|
|[[:human genes:z:zmynd8|ZMYND8]]|0.433|
|[[:human genes:e:eif4e|EIF4E]]|0.433|
|[[:human genes:t:tti2|TTI2]]|0.428|
|[[:human genes:a:aars|AARS]]|0.426|
|[[:human genes:t:tada3|TADA3]]|0.426|
|[[:human genes:r:rptor|RPTOR]]|0.425|
|[[:human genes:m:med13l|MED13L]]|0.424|
|[[:human genes:d:ddost|DDOST]]|0.422|
|[[:human genes:m:mapk14|MAPK14]]|0.422|
|[[:human genes:t:taf5l|TAF5L]]|0.419|
|[[:human genes:d:dpagt1|DPAGT1]]|0.414|
|[[:human genes:m:med13|MED13]]|0.414|
|[[:human genes:p:pelo|PELO]]|0.414|
|[[:human genes:t:tada1|TADA1]]|0.411|
|[[:human genes:e:ehmt2|EHMT2]]|0.411|
|[[:human genes:d:derl2|DERL2]]|0.402|
|[[:human genes:t:tle4|TLE4]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 22/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/28|
|bone|3/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|2/21|
|liver|0/20|
|lung|2/75|
|lymphocyte|1/16|
|ovary|1/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|2/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 494
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.49 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MAX Expression in NALM6 Cells: 5.49'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>