MBD1 [The Human Chemical-Genetic Interaction Map Project]

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======= MBD1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MBD1
  * **<color #00a2e8>Official Name</color>**: methyl-CpG binding domain protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4152|4152]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UIS9|Q9UIS9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MBD1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MBD1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/156535|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of a family of nuclear proteins related by the presence of a methyl-CpG binding domain (MBD). These proteins are capable of binding specifically to methylated DNA, and some members can also repress transcription from methylated gene promoters. This protein contains multiple domains: MBD at the N-terminus that functions both in binding to methylated DNA and in protein interactions; several CXXC-type zinc finger domains that mediate binding to non-methylated CpG dinucleotides; transcriptional repression domain (TRD) at the C-terminus that is involved in transcription repression and in protein interactions. Numerous alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Feb 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|MBD|
|zf-CXXC|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|double-stranded methylated DNA binding|
|negative regulation of astrocyte differentiation|
|methylation-dependent chromatin silencing|
|regulation of DNA methylation|
|negative regulation of glial cell differentiation|
|methyl-CpG binding|
|regulation of astrocyte differentiation|
|negative regulation of gliogenesis|
|response to cocaine|
|chromatin organization involved in negative regulation of transcription|
|chromatin silencing|
|regulation of glial cell differentiation|
|chromatin organization involved in regulation of transcription|
|response to anesthetic|
|negative regulation of gene expression, epigenetic|
|nuclear matrix|
|response to alkaloid|
|regulation of gliogenesis|
|response to estradiol|
|gene silencing|
|response to ammonium ion|
|regulation of gene expression, epigenetic|
|nuclear chromatin|
|aging|
|negative regulation of neurogenesis|
|response to xenobiotic stimulus|
|negative regulation of nervous system development|
|negative regulation of cell development|
|regulation of DNA metabolic process|
|covalent chromatin modification|
|chromatin binding|
|nuclear speck|
|transcription by RNA polymerase II|
|response to nutrient levels|
|heart development|
|response to extracellular stimulus|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|chromatin organization|
|negative regulation of cell differentiation|
|regulation of neurogenesis|
|zinc ion binding|
|response to lipid|
|negative regulation of transcription by RNA polymerase II|
|circulatory system development|
|response to hormone|
|response to organic cyclic compound|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|response to organonitrogen compound|
|neuron differentiation|
|response to drug|
|chromosome organization|
|response to nitrogen compound|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|organic cyclic compound biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|neurogenesis|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|macromolecule biosynthetic process|
|regulation of cell differentiation|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|-2.45|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|-2.05|
|[[:results:exp417|Tubastatin-A 2.5μM R07 exp417]]|-1.97|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|-1.87|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|-1.73|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|-1.72|
|[[:results:exp108|Vinblastine 0.2μM R03 exp108]]|-1.71|
|[[:results:exp362|GSK-J4 1μM R07 exp362]]|1.97|
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|2.24|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16447
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.9 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MBD1 Expression in NALM6 Cells: 6.9'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>