MBP [The Human Chemical-Genetic Interaction Map Project]

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======= MBP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MBP
  * **<color #00a2e8>Official Name</color>**: myelin basic protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4155|4155]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P02686|P02686]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MBP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MBP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/159430|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Myelin MBP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|maintenance of permeability of blood-brain barrier|
|positive regulation of metalloendopeptidase activity|
|regulation of chemokine (C-C motif) ligand 2 secretion|
|compact myelin|
|internode region of axon|
|positive regulation of chemokine (C-C motif) ligand 2 secretion|
|regulation of metalloendopeptidase activity|
|positive regulation of metallopeptidase activity|
|positive regulation of chemokine (C-X-C motif) ligand 2 production|
|structural constituent of myelin sheath|
|regulation of cell-cell adhesion involved in gastrulation|
|negative regulation of heterotypic cell-cell adhesion|
|regulation of chemokine (C-X-C motif) ligand 2 production|
|regulation of metallopeptidase activity|
|positive regulation of chemokine secretion|
|regulation of chemokine secretion|
|regulation of heterotypic cell-cell adhesion|
|positive regulation of interleukin-6 secretion|
|myelin sheath|
|regulation of gastrulation|
|cell periphery|
|substantia nigra development|
|positive regulation of chemokine production|
|neural nucleus development|
|regulation of chemokine production|
|midbrain development|
|positive regulation of interleukin-6 production|
|protease binding|
|myelination|
|axon ensheathment|
|ensheathment of neurons|
|regulation of embryonic development|
|positive regulation of cytokine secretion|
|regulation of interleukin-6 production|
|sensory perception of sound|
|sensory perception of mechanical stimulus|
|positive regulation of endopeptidase activity|
|negative regulation of cell-cell adhesion|
|positive regulation of peptidase activity|
|calmodulin binding|
|regulation of cytokine secretion|
|positive regulation of protein secretion|
|negative regulation of cell adhesion|
|positive regulation of peptide secretion|
|positive regulation of proteolysis|
|MAPK cascade|
|neuronal cell body|
|signal transduction by protein phosphorylation|
|regulation of cell-cell adhesion|
|positive regulation of secretion by cell|
|regulation of endopeptidase activity|
|anterograde trans-synaptic signaling|
|chemical synaptic transmission|
|positive regulation of protein transport|
|positive regulation of secretion|
|trans-synaptic signaling|
|regulation of peptidase activity|
|positive regulation of cytokine production|
|positive regulation of establishment of protein localization|
|synaptic signaling|
|regulation of protein secretion|
|regulation of peptide secretion|
|response to toxic substance|
|protein-containing complex|
|cell surface|
|regulation of cell adhesion|
|regulation of cytokine production|
|regulation of protein transport|
|regulation of proteolysis|
|regulation of peptide transport|
|brain development|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|positive regulation of hydrolase activity|
|head development|
|regulation of secretion|
|membrane organization|
|sensory perception|
|protein phosphorylation|
|central nervous system development|
|positive regulation of transport|
|regulation of protein localization|
|regulation of anatomical structure morphogenesis|
|cell-cell signaling|
|regulation of hydrolase activity|
|phosphorylation|
|nervous system process|
|positive regulation of catalytic activity|
|positive regulation of cellular protein metabolic process|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of transport|
|immune response|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16616
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.42 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MBP Expression in NALM6 Cells: 6.42'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>