MCM3 [The Human Chemical-Genetic Interaction Map Project]

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======= MCM3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MCM3
  * **<color #00a2e8>Official Name</color>**: minichromosome maintenance complex component 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4172|4172]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P25205|P25205]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MCM3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MCM3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602693|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for DNA replication and cell proliferation.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|MCM|
|Mg chelatase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitotic DNA replication initiation|
|cell cycle DNA replication initiation|
|nuclear cell cycle DNA replication initiation|
|alpha DNA polymerase:primase complex|
|pre-replicative complex assembly involved in cell cycle DNA replication|
|pre-replicative complex assembly|
|pre-replicative complex assembly involved in nuclear cell cycle DNA replication|
|double-strand break repair via break-induced replication|
|mitotic DNA replication|
|MCM complex|
|DNA strand elongation involved in DNA replication|
|DNA strand elongation|
|DNA replication origin binding|
|DNA replication initiation|
|nuclear DNA replication|
|cell cycle DNA replication|
|DNA helicase activity|
|double-strand break repair via homologous recombination|
|recombinational repair|
|single-stranded DNA binding|
|nuclear chromosome, telomeric region|
|DNA duplex unwinding|
|DNA geometric change|
|G1/S transition of mitotic cell cycle|
|cell cycle G1/S phase transition|
|DNA-dependent DNA replication|
|double-strand break repair|
|protein-DNA complex assembly|
|DNA replication|
|DNA recombination|
|protein-DNA complex subunit organization|
|mitotic cell cycle phase transition|
|cell cycle phase transition|
|DNA conformation change|
|centrosome|
|DNA repair|
|mitotic cell cycle process|
|mitotic cell cycle|
|perinuclear region of cytoplasm|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|cellular protein-containing complex assembly|
|nucleolus|
|cell cycle process|
|chromosome organization|
|cell cycle|
|DNA binding|
|ATP binding|
|protein-containing complex assembly|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|-1.88|
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|-1.82|
|[[:results:exp10|CCCP 0.1μM R00 exp10]]|-1.81|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|-1.74|
|[[:results:exp156|UNC2400 2μM R03 exp156]]|1.73|
|[[:results:exp133|MKC9989 10μM R03 exp133]]|1.78|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 188/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|3/28|
|blood|7/28|
|bone|9/26|
|breast|13/33|
|central nervous system|7/56|
|cervix|1/4|
|colorectal|7/17|
|esophagus|2/13|
|fibroblast|0/1|
|gastric|6/16|
|kidney|9/21|
|liver|9/20|
|lung|19/75|
|lymphocyte|5/16|
|ovary|3/26|
|pancreas|5/24|
|peripheral nervous system|2/16|
|plasma cell|4/15|
|prostate|0/1|
|skin|4/24|
|soft tissue|2/9|
|thyroid|0/2|
|upper aerodigestive|6/22|
|urinary tract|5/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1139
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 9.01 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MCM3 Expression in NALM6 Cells: 9.01'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>