MCMBP [The Human Chemical-Genetic Interaction Map Project]

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======= MCMBP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MCMBP
  * **<color #00a2e8>Official Name</color>**: minichromosome maintenance complex binding protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=79892|79892]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BTE3|Q9BTE3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MCMBP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MCMBP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610909|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Associated component of the MCM complex that acts as a regulator of DNA replication. Binds to the MCM complex during late S phase and promotes the disassembly of the MCM complex from chromatin, thereby acting as a key regulator of pre-replication complex (pre-RC) unloading from replicated DNA. Can dissociate the MCM complex without addition of ATP; probably acts by destabilizing interactions of each individual subunits of the MCM complex. Required for sister chromatid cohesion. {ECO:0000269|PubMed:20090939, ECO:0000269|PubMed:21196493}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF2044|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|MCM complex|
|sister chromatid cohesion|
|DNA-dependent DNA replication|
|sister chromatid segregation|
|DNA replication|
|nuclear chromosome segregation|
|nuclear chromatin|
|chromosome segregation|
|chromatin binding|
|cell division|
|cell cycle process|
|chromosome organization|
|cell cycle|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|-1.76|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|1.8|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.493|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 102/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|5/28|
|blood|3/28|
|bone|6/25|
|breast|10/33|
|central nervous system|15/56|
|cervix|1/4|
|colorectal|3/17|
|esophagus|2/13|
|fibroblast|1/1|
|gastric|1/15|
|kidney|4/21|
|liver|6/20|
|lung|5/75|
|lymphocyte|2/14|
|ovary|2/26|
|pancreas|4/24|
|peripheral nervous system|2/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|6/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|2/22|
|urinary tract|0/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 748
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.45 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MCMBP Expression in NALM6 Cells: 7.45'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>