MCOLN2 [The Human Chemical-Genetic Interaction Map Project]

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======= MCOLN2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MCOLN2
  * **<color #00a2e8>Official Name</color>**: mucolipin 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=255231|255231]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8IZK6|Q8IZK6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MCOLN2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MCOLN2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607399|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Nonselective cation channel probably playing a role in the regulation of membrane trafficking events. Acts as Ca(2+)- permeable cation channel with inwardly rectifying activity (PubMed:19940139, PubMed:19885840). May activate ARF6 and be involved in the trafficking of GPI-anchored cargo proteins to the cell surface via the ARF6-regulated recycling pathway (PubMed:17662026). May play a role in immune processes. In adaptive immunity, TRPML2 and TRPML1 may play redundant roles in the function of the specialized lysosomes of B cells (By similarity). In the innate immune response, may play a role in the regulation of chemokine secretion and macrophage migration (By similarity). Through a possible and probably tissue-specific heteromerization with MCOLN1 may be at least in part involved in many lysosome-dependent cellular events (PubMed:19885840). {ECO:0000250|UniProtKB:Q8K595, ECO:0000269|PubMed:17662026, ECO:0000269|PubMed:19885840, ECO:0000269|PubMed:19940139, ECO:0000305}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PKD channel|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of macrophage inflammatory protein 1 alpha production|
|chemokine (C-X-C motif) ligand 2 production|
|chemokine (C-C motif) ligand 2 secretion|
|chemokine secretion|
|NAADP-sensitive calcium-release channel activity|
|positive regulation of chemokine (C-C motif) ligand 5 production|
|regulation of macrophage inflammatory protein 1 alpha production|
|regulation of chemokine (C-C motif) ligand 5 production|
|chemokine production|
|positive regulation of chemokine (C-X-C motif) ligand 2 production|
|positive regulation of monocyte chemotactic protein-1 production|
|regulation of chemokine (C-X-C motif) ligand 2 production|
|regulation of monocyte chemotactic protein-1 production|
|macrophage migration|
|cytokine secretion|
|release of sequestered calcium ion into cytosol|
|positive regulation of chemokine production|
|negative regulation of sequestering of calcium ion|
|calcium ion transmembrane import into cytosol|
|calcium ion transport into cytosol|
|regulation of chemokine production|
|recycling endosome membrane|
|cytosolic calcium ion transport|
|neutrophil migration|
|granulocyte migration|
|late endosome membrane|
|regulation of sequestering of calcium ion|
|myeloid leukocyte migration|
|cytokine production|
|protein secretion|
|establishment of protein localization to extracellular region|
|protein localization to extracellular region|
|peptide secretion|
|calcium ion transmembrane transport|
|calcium ion transport|
|positive regulation of cytosolic calcium ion concentration|
|divalent metal ion transport|
|lysosomal membrane|
|divalent inorganic cation transport|
|regulation of cytosolic calcium ion concentration|
|leukocyte migration|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|positive regulation of cytokine production|
|cellular divalent inorganic cation homeostasis|
|divalent inorganic cation homeostasis|
|protein complex oligomerization|
|cellular metal ion homeostasis|
|inorganic cation transmembrane transport|
|adaptive immune response|
|cation transmembrane transport|
|metal ion homeostasis|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|regulation of cytokine production|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|innate immune response|
|ion homeostasis|
|cation transport|
|cellular homeostasis|
|ion transmembrane transport|
|defense response to other organism|
|cell migration|
|secretion by cell|
|export from cell|
|cell motility|
|localization of cell|
|chemical homeostasis|
|secretion|
|transmembrane transport|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|response to biotic stimulus|
|defense response|
|ion transport|
|protein transport|
|peptide transport|
|movement of cell or subcellular component|
|protein-containing complex assembly|
|amide transport|
|establishment of protein localization|
|homeostatic process|
|positive regulation of multicellular organismal process|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.404|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14949
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.15 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MCOLN2 Expression in NALM6 Cells: 2.15'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>