MCUR1 [The Human Chemical-Genetic Interaction Map Project]

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======= MCUR1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MCUR1
  * **<color #00a2e8>Official Name</color>**: mitochondrial calcium uniporter regulator 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=63933|63933]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96AQ8|Q96AQ8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MCUR1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MCUR1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616952|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Key regulator of mitochondrial calcium uniporter (MCU) required for calcium entry into mitochondrion (PubMed:23178883, PubMed:26445506, PubMed:27184846, PubMed:26976564). Plays a direct role in uniporter-mediated calcium uptake via a direct interaction with MCU (PubMed:23178883). Probably involved in the assembly of the membrane components of the uniporter complex (uniplex) (PubMed:27184846). {ECO:0000269|PubMed:23178883, ECO:0000269|PubMed:26445506, ECO:0000269|PubMed:26976564, ECO:0000269|PubMed:27184846}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF1640|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|calcium import into the mitochondrion|
|positive regulation of mitochondrial calcium ion concentration|
|mitochondrial calcium ion transmembrane transport|
|mitochondrial calcium ion homeostasis|
|integral component of mitochondrial inner membrane|
|calcium ion import|
|cytosolic calcium ion transport|
|mitochondrial transmembrane transport|
|calcium ion transmembrane transport|
|mitochondrial transport|
|calcium ion transport|
|divalent metal ion transport|
|divalent inorganic cation transport|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|cellular divalent inorganic cation homeostasis|
|divalent inorganic cation homeostasis|
|cellular metal ion homeostasis|
|inorganic cation transmembrane transport|
|cation transmembrane transport|
|metal ion homeostasis|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|ion homeostasis|
|cation transport|
|cellular homeostasis|
|ion transmembrane transport|
|chemical homeostasis|
|mitochondrion|
|transmembrane transport|
|ion transport|
|homeostatic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|1.7|
|[[:results:exp344|Chlorpromazine 10μM R07 exp344]]|1.71|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|1.75|
|[[:results:exp307|Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307]]|1.76|
|[[:results:exp359|FK-506 30μM R07 exp359]]|1.76|
|[[:results:exp183|IU1-C 25μM R04 exp183]]|1.84|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|1.85|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|1.92|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|1.96|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|2.05|
|[[:results:exp83|Trametinib 10μM R02 exp83]]|2.07|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|2.12|
|[[:results:exp433|LJH685 50μM R08 exp433]]|2.17|
|[[:results:exp360|Genistein 15μM R07 exp360]]|2.21|
|[[:results:exp483|FTY720 3μM R08 exp483]]|2.89|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:x:xpnpep3|XPNPEP3]]|0.508|
|[[:human genes:p:prepl|PREPL]]|0.472|
|[[:human genes:c:ccdc90b|CCDC90B]]|0.468|
|[[:human genes:d:ddx28|DDX28]]|0.466|
|[[:human genes:f:fastkd2|FASTKD2]]|0.462|
|[[:human genes:m:mpv17l2|MPV17L2]]|0.46|
|[[:human genes:p:pde12|PDE12]]|0.437|
|[[:human genes:e:eral1|ERAL1]]|0.412|
|[[:human genes:m:mettl17|METTL17]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 614
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.96 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MCUR1 Expression in NALM6 Cells: 5.96'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>