MDH2 [The Human Chemical-Genetic Interaction Map Project]

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======= MDH2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MDH2
  * **<color #00a2e8>Official Name</color>**: malate dehydrogenase 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4191|4191]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P40926|P40926]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MDH2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MDH2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/154100|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Malate dehydrogenase catalyzes the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofactor system in the citric acid cycle. The protein encoded by this gene is localized to the mitochondria and may play pivotal roles in the malate-aspartate shuttle that operates in the metabolic coordination between cytosol and mitochondria. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ldh 1 C|
|Ldh 1 N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|malate dehydrogenase (NADP+) activity|
|L-malate dehydrogenase activity|
|oxaloacetate metabolic process|
|malate metabolic process|
|tricarboxylic acid cycle|
|NADH metabolic process|
|gluconeogenesis|
|hexose biosynthetic process|
|monosaccharide biosynthetic process|
|protein self-association|
|aerobic respiration|
|dicarboxylic acid metabolic process|
|glucose metabolic process|
|internal protein amino acid acetylation|
|carbohydrate biosynthetic process|
|protein acetylation|
|hexose metabolic process|
|cellular respiration|
|protein acylation|
|monosaccharide metabolic process|
|energy derivation by oxidation of organic compounds|
|mitochondrial matrix|
|generation of precursor metabolites and energy|
|carbohydrate metabolic process|
|small molecule biosynthetic process|
|carboxylic acid metabolic process|
|oxidation-reduction process|
|oxoacid metabolic process|
|organic acid metabolic process|
|mitochondrion|
|RNA binding|
|small molecule metabolic process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|-3.49|
|[[:results:exp224|CB-839 10μM R05 exp224]]|-2.57|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|-2.34|
|[[:results:exp219|A-395N 10μM R05 exp219]]|-1.74|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|1.71|
|[[:results:exp143|Phenformin 20μM R03 exp143]]|1.73|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|1.76|
|[[:results:exp506|Momordin-Ic 10μM R08 exp506]]|1.79|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|1.79|
|[[:results:exp530|Thioridazine 5μM R08 exp530]]|1.84|
|[[:results:exp83|Trametinib 10μM R02 exp83]]|1.86|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|2.14|
|[[:results:exp82|Torin1 0.08μM R02 exp82]]|2.14|
|[[:results:exp475|CyclicAMP 200μM R08 exp475]]|2.22|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|2.86|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|3.15|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:g:got2|GOT2]]|0.467|
|[[:human genes:m:mto1|MTO1]]|0.437|
|[[:human genes:p:prim1|PRIM1]]|0.43|
|[[:human genes:g:grsf1|GRSF1]]|0.429|
|[[:human genes:n:nubpl|NUBPL]]|0.428|
|[[:human genes:p:pet117|PET117]]|0.408|
|[[:human genes:f:fastkd2|FASTKD2]]|0.407|
|[[:human genes:m:mtif2|MTIF2]]|0.403|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 3/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|2/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1908
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.23 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MDH2 Expression in NALM6 Cells: 7.23'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>