MED1 [The Human Chemical-Genetic Interaction Map Project]

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======= MED1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MED1
  * **<color #00a2e8>Official Name</color>**: mediator complex subunit 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5469|5469]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q15648|Q15648]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MED1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MED1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604311|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. It also regulates p53-dependent apoptosis and it is essential for adipogenesis. This protein is known to have the ability to self-oligomerize. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (PubMed:10406464, PubMed:11867769, PubMed:12037571, PubMed:12218053, PubMed:12556447, PubMed:14636573, PubMed:15340084, PubMed:15471764, PubMed:15989967, PubMed:16574658, PubMed:9653119). Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781). {ECO:0000269|PubMed:10406464, ECO:0000269|PubMed:11867769, ECO:0000269|PubMed:12037571, ECO:0000269|PubMed:12218053, ECO:0000269|PubMed:12556447, ECO:0000269|PubMed:14636573, ECO:0000269|PubMed:15340084, ECO:0000269|PubMed:15471764, ECO:0000269|PubMed:15989967, ECO:0000269|PubMed:16574658, ECO:0000269|PubMed:24245781, ECO:0000269|PubMed:9653119}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Med1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|enucleate erythrocyte development|
|thyroid hormone mediated signaling pathway|
|retinal pigment epithelium development|
|positive regulation of G0 to G1 transition|
|thyroid hormone receptor coactivator activity|
|epithelial cell proliferation involved in mammary gland duct elongation|
|mediator complex binding|
|branch elongation involved in mammary gland duct branching|
|mammary gland branching involved in thelarche|
|thelarche|
|mammary gland branching involved in pregnancy|
|positive regulation of response to interferon-gamma|
|regulation of vitamin D receptor signaling pathway|
|positive regulation of interferon-gamma-mediated signaling pathway|
|development of secondary female sexual characteristics|
|peroxisome proliferator activated receptor signaling pathway|
|enucleate erythrocyte differentiation|
|LBD domain binding|
|positive regulation of hepatocyte proliferation|
|development of secondary sexual characteristics|
|androgen biosynthetic process|
|peroxisome proliferator activated receptor binding|
|thyroid hormone generation|
|positive regulation of intracellular estrogen receptor signaling pathway|
|mammary gland epithelial cell proliferation|
|retinoic acid receptor binding|
|negative regulation of keratinocyte proliferation|
|regulation of hepatocyte proliferation|
|positive regulation of intracellular steroid hormone receptor signaling pathway|
|vitamin D receptor binding|
|cellular response to thyroid hormone stimulus|
|thyroid hormone metabolic process|
|positive regulation of keratinocyte differentiation|
|ventricular trabecula myocardium morphogenesis|
|cellular response to hepatocyte growth factor stimulus|
|mononuclear cell differentiation|
|monocyte differentiation|
|megakaryocyte development|
|branch elongation of an epithelium|
|response to hepatocyte growth factor|
|mRNA transcription by RNA polymerase II|
|nuclear receptor binding|
|embryonic hemopoiesis|
|megakaryocyte differentiation|
|branching involved in mammary gland duct morphogenesis|
|positive regulation of epidermal cell differentiation|
|regulation of response to interferon-gamma|
|regulation of response to nutrient levels|
|regulation of interferon-gamma-mediated signaling pathway|
|regulation of response to extracellular stimulus|
|bone cell development|
|mRNA transcription|
|nuclear hormone receptor binding|
|response to thyroid hormone|
|androgen metabolic process|
|axis elongation|
|embryonic hindlimb morphogenesis|
|ERK1 and ERK2 cascade|
|thyroid hormone receptor binding|
|positive regulation of erythrocyte differentiation|
|mammary gland duct morphogenesis|
|regulation of transcription by RNA polymerase I|
|heart trabecula morphogenesis|
|erythrocyte development|
|regulation of keratinocyte proliferation|
|RNA polymerase II core promoter sequence-specific DNA binding|
|positive regulation of signaling receptor activity|
|hindlimb morphogenesis|
|mediator complex|
|positive regulation of epidermis development|
|regulation of keratinocyte differentiation|
|regulation of intracellular estrogen receptor signaling pathway|
|mammary gland morphogenesis|
|estrogen receptor binding|
|cellular response to epidermal growth factor stimulus|
|regulation of G0 to G1 transition|
|protein-DNA complex|
|lactation|
|trabecula morphogenesis|
|regulation of erythrocyte differentiation|
|steroid hormone biosynthetic process|
|response to epidermal growth factor|
|ventricular cardiac muscle tissue morphogenesis|
|positive regulation of cytokine-mediated signaling pathway|
|ventricular cardiac muscle tissue development|
|positive regulation of response to cytokine stimulus|
|mammary gland epithelium development|
|myeloid cell development|
|positive regulation of epithelial cell differentiation|
|hormone biosynthetic process|
|regulation of epidermal cell differentiation|
|maternal process involved in female pregnancy|
|nuclear receptor transcription coactivator activity|
|cardiac muscle tissue morphogenesis|
|intracellular steroid hormone receptor signaling pathway|
|chromatin DNA binding|
|animal organ regeneration|
|cardiac ventricle morphogenesis|
|body fluid secretion|
|embryonic heart tube development|
|regulation of intracellular steroid hormone receptor signaling pathway|
|lens development in camera-type eye|
|muscle tissue morphogenesis|
|erythrocyte differentiation|
|positive regulation of animal organ morphogenesis|
|transcription coregulator activity|
|phenol-containing compound metabolic process|
|regulation of epidermis development|
|epithelial cell proliferation|
|muscle organ morphogenesis|
|embryonic placenta development|
|erythrocyte homeostasis|
|positive regulation of myeloid cell differentiation|
|protein import into nucleus|
|gland morphogenesis|
|ubiquitin ligase complex|
|fat cell differentiation|
|myeloid cell homeostasis|
|myeloid leukocyte differentiation|
|import into nucleus|
|developmental growth involved in morphogenesis|
|chromatin|
|steroid hormone mediated signaling pathway|
|cellular hormone metabolic process|
|negative regulation of epithelial cell proliferation|
|embryonic limb morphogenesis|
|embryonic appendage morphogenesis|
|liver development|
|cardiac chamber morphogenesis|
|steroid biosynthetic process|
|cardiac ventricle development|
|mammary gland development|
|hepaticobiliary system development|
|branching morphogenesis of an epithelial tube|
|retina development in camera-type eye|
|regulation of epithelial cell differentiation|
|protein import|
|appendage morphogenesis|
|limb morphogenesis|
|placenta development|
|regeneration|
|morphogenesis of a branching epithelium|
|cardiac muscle tissue development|
|protein localization to nucleus|
|intracellular receptor signaling pathway|
|regulation of cytokine-mediated signaling pathway|
|morphogenesis of a branching structure|
|cardiac chamber development|
|hormone-mediated signaling pathway|
|regulation of signaling receptor activity|
|transcription initiation from RNA polymerase II promoter|
|regulation of response to cytokine stimulus|
|female pregnancy|
|appendage development|
|limb development|
|positive regulation of hemopoiesis|
|cellular response to steroid hormone stimulus|
|positive regulation of epithelial cell proliferation|
|cellular modified amino acid metabolic process|
|homeostasis of number of cells|
|bone development|
|hormone metabolic process|
|multi-multicellular organism process|
|DNA-templated transcription, initiation|
|myeloid cell differentiation|
|ubiquitin protein ligase activity|
|negative regulation of neuron differentiation|
|regulation of myeloid cell differentiation|
|transcription corepressor activity|
|heart morphogenesis|
|regulation of animal organ morphogenesis|
|steroid metabolic process|
|nucleocytoplasmic transport|
|nuclear transport|
|keratinocyte differentiation|
|transcription coactivator activity|
|striated muscle tissue development|
|positive regulation of cell cycle process|
|negative regulation of neurogenesis|
|muscle organ development|
|muscle tissue development|
|epithelial tube morphogenesis|
|negative regulation of nervous system development|
|camera-type eye development|
|epidermal cell differentiation|
|angiogenesis|
|response to steroid hormone|
|leukocyte differentiation|
|transcription factor binding|
|regulation of epithelial cell proliferation|
|negative regulation of cell development|
|positive regulation of innate immune response|
|eye development|
|visual system development|
|positive regulation of response to biotic stimulus|
|sensory system development|
|MAPK cascade|
|positive regulation of cell cycle|
|in utero embryonic development|
|skin development|
|developmental growth|
|growth|
|signal transduction by protein phosphorylation|
|chromatin binding|
|regulation of lipid metabolic process|
|blood vessel morphogenesis|
|gland development|
|epidermis development|
|reproductive structure development|
|reproductive system development|
|morphogenesis of an epithelium|
|establishment of protein localization to organelle|
|embryonic organ development|
|regulation of hemopoiesis|
|regulation of innate immune response|
|organic hydroxy compound metabolic process|
|positive regulation of defense response|
|muscle structure development|
|transcription by RNA polymerase II|
|blood vessel development|
|skeletal system development|
|regulation of body fluid levels|
|cellular response to growth factor stimulus|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|positive regulation of multi-organism process|
|vasculature development|
|cardiovascular system development|
|cellular response to lipid|
|regulation of response to biotic stimulus|
|heart development|
|response to growth factor|
|regulation of hormone levels|
|cellular response to organic cyclic compound|
|sensory organ development|
|cell population proliferation|
|hemopoiesis|
|tissue morphogenesis|
|embryonic morphogenesis|
|lipid biosynthetic process|
|positive regulation of response to external stimulus|
|cellular response to hormone stimulus|
|hematopoietic or lymphoid organ development|
|chordate embryonic development|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|immune system development|
|embryo development ending in birth or egg hatching|
|RNA biosynthetic process|
|tube morphogenesis|
|regulation of neuron differentiation|
|developmental process involved in reproduction|
|negative regulation of cell population proliferation|
|epithelial cell differentiation|
|protein ubiquitination|
|mRNA metabolic process|
|negative regulation of cell differentiation|
|cell morphogenesis|
|protein localization to organelle|
|brain development|
|regulation of cell cycle process|
|regulation of defense response|
|protein modification by small protein conjugation|
|regulation of multi-organism process|
|head development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|multicellular organismal reproductive process|
|multicellular organism reproduction|
|tube development|
|response to lipid|
|nucleolus|
|negative regulation of transcription by RNA polymerase II|
|positive regulation of immune response|
|circulatory system development|
|negative regulation of apoptotic process|
|anatomical structure formation involved in morphogenesis|
|negative regulation of programmed cell death|
|response to hormone|
|positive regulation of cell population proliferation|
|response to organic cyclic compound|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|animal organ morphogenesis|
|positive regulation of cell differentiation|
|protein phosphorylation|
|embryo development|
|central nervous system development|
|protein modification by small protein conjugation or removal|
|intracellular protein transport|
|multi-organism reproductive process|
|negative regulation of cell death|
|regulation of anatomical structure morphogenesis|
|regulation of response to external stimulus|
|nucleobase-containing compound biosynthetic process|
|epithelium development|
|secretion|
|regulation of immune response|
|positive regulation of immune system process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|lipid metabolic process|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|phosphorylation|
|organic cyclic compound biosynthetic process|
|negative regulation of RNA metabolic process|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|regulation of response to stress|
|protein transport|
|negative regulation of cellular biosynthetic process|
|intracellular transport|
|generation of neurons|
|peptide transport|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|regulation of programmed cell death|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|regulation of cell population proliferation|
|neurogenesis|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|cell development|
|positive regulation of signal transduction|
|regulation of immune system process|
|RNA metabolic process|
|regulation of cell death|
|intracellular signal transduction|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|macromolecule biosynthetic process|
|positive regulation of molecular function|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|establishment of localization in cell|
|nitrogen compound transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|membrane|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|-2.3|
|[[:results:exp99|NFN1 0.4μM R03 exp99]]|-2.26|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|-2.2|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|-2.1|
|[[:results:exp495|IWR1 50μM R08 exp495]]|-1.93|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|1.71|
|[[:results:exp271|CCT251545 0.2μM R06 exp271]]|1.73|
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|1.77|
|[[:results:exp311|2-Methoxyestradiol 0.55 to 0.75μM  on day4 R07 exp311]]|1.81|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|1.84|
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|1.86|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|1.95|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|1.98|
|[[:results:exp363|GSK-J4 1-1.25μM to day4 R07 exp363]]|2.06|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|2.06|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|2.1|
|[[:results:exp293|Myriocin 25μM R06 exp293]]|2.12|
|[[:results:exp59|UMK57 1μM R01 exp59]]|2.51|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:med10|MED10]]|0.474|
|[[:human genes:m:med13|MED13]]|0.469|
|[[:human genes:p:polr2j3|POLR2J3]]|0.446|
|[[:human genes:r:ranbp3|RANBP3]]|0.409|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 284/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|14/28|
|blood|22/28|
|bone|7/25|
|breast|14/33|
|central nervous system|17/56|
|cervix|1/4|
|colorectal|5/17|
|esophagus|3/13|
|fibroblast|0/1|
|gastric|6/15|
|kidney|4/21|
|liver|5/20|
|lung|22/75|
|lymphocyte|7/14|
|ovary|10/26|
|pancreas|13/24|
|peripheral nervous system|7/16|
|plasma cell|14/15|
|prostate|1/1|
|skin|12/24|
|soft tissue|3/7|
|thyroid|1/2|
|upper aerodigestive|2/22|
|urinary tract|15/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 109
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.21 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MED1 Expression in NALM6 Cells: 7.21'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>