MED28 [The Human Chemical-Genetic Interaction Map Project]

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======= MED28 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MED28
  * **<color #00a2e8>Official Name</color>**: mediator complex subunit 28
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=80306|80306]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H204|Q9H204]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=MED28&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20MED28|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610311|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May be part of a complex containing NF2/merlin that participates in cellular signaling to the actin cytoskeleton downstream of tyrosine kinase signaling pathways. {ECO:0000269|PubMed:15467741}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Med28|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of smooth muscle cell differentiation|
|regulation of smooth muscle cell differentiation|
|mediator complex|
|cortical actin cytoskeleton|
|negative regulation of muscle cell differentiation|
|stem cell population maintenance|
|maintenance of cell number|
|regulation of muscle cell differentiation|
|actin binding|
|negative regulation of cell differentiation|
|negative regulation of developmental process|
|regulation of cell differentiation|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|-2.05|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|1.8|
|[[:results:exp247|UM0130462 0.025 to 0.035μM day4 R05 exp247]]|2.11|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|2.13|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:ccna2|CCNA2]]|0.408|
|[[:human genes:n:ngdn|NGDN]]|0.405|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 82/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|2/28|
|blood|2/28|
|bone|6/25|
|breast|5/33|
|central nervous system|6/56|
|cervix|1/4|
|colorectal|3/17|
|esophagus|2/13|
|fibroblast|0/1|
|gastric|4/15|
|kidney|1/21|
|liver|4/20|
|lung|7/75|
|lymphocyte|2/14|
|ovary|3/26|
|pancreas|1/24|
|peripheral nervous system|4/16|
|plasma cell|4/15|
|prostate|0/1|
|skin|4/24|
|soft tissue|1/7|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|4/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2024
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.05 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='MED28 Expression in NALM6 Cells: 7.05'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>